Childhood Cancer and Industrial Pollution (CHIP)

项目摘要 癌症是儿童疾病死亡的主要原因，预计有11，060名儿童患有癌症。 2019年的案件。儿童癌症的影响超出了早期生命，幸存者减少了 健康状况和慢性健康问题的风险比一般人群更大。在成年人中， 明确地确定，职业暴露于非常高水平的特定物质会增加癌症的发生， 风险公众强烈怀疑环境毒素在病因学上与儿科癌症有关， 重要的是，系统地研究儿童癌症的环境决定因素， 支持或反驳这些联系。拟议的项目是一项以人群为基础的病例对照研究， 怀孕和幼儿期工业污染与儿童癌症发展的关系。我们提出 从NIH资助的两项研究（空气污染和儿童癌症研究和杀虫剂研究）中选取病例， 接触和儿童癌症研究），并审查住宅区与工业污染源的接近程度; 我们先前已经为我们的样本的一部分重建了完整的住宅历史。对照者 从加州出生记录中随机抽取（N= 29，445例特定儿童癌症类型，983，440 对照）。暴露测量将从环境保护局的有毒物质释放 库存（TRI）。拟议研究中主要关注的暴露包括疑似和确定的暴露 这些致癌物质是加州工业中最常见的有毒物质。我们将 国际研究机构重点关注特别感兴趣的致癌物审查 癌该研究丰富的其他环境暴露和潜在混杂因素的现有数据， 除了使用地理信息系统开发详细的暴露指标外，还将使调查人员能够 对目前有关儿科环境原因的知识状况做出了可操作的贡献 癌的

Project summary Cancer is the leading cause of death by disease among children, with an expected 11,060 childhood cancer cases in 2019. The effects of pediatric cancers extend beyond early life, with survivors having diminished health status and a greater risk for chronic health problems in comparison to the general population. In adults, it is clearly established that occupational exposure to very high levels of specific agents has increased cancer risks. Environmental toxins are strongly suspected by the public to contribute etiologically to pediatric cancers, and it is important that the environmental determinants of pediatric cancers are systematically investigated to support or refute these links. The proposed project is a population-based case-control study of exposure to industrial pollution in pregnancy and early childhood in relation to childhood cancer development. We propose to take cases from two NIH-funded studies (the Air Pollution and Childhood Cancers study and the Pesticide Exposure and Childhood Cancers study) and examine residential proximity to sources of industrial pollution; we have previously reconstructed full residential histories for a portion of our sample. Controls were selected at random from California birth records (N=29,445 cases of specified childhood cancer types, 983,440 controls). Exposure measurements will be taken from the Environmental Protection Agency's Toxics Release Inventory (TRI). The exposures of primary interest in the proposed study include suspected and established carcinogens which are amongst the most commonly released toxic agents by industries in California. We will focus on agents of particular interest for carcinogenic review by the International Agency for Research on Cancer. The study's wealth of existing data on other environmental exposures and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make an actionable contribution to the current state of knowledge regarding environmental causes of pediatric cancers.