Data and Statistical Core

数据和统计核心 项目摘要 由杰克逊实验室内森休克中心（JAX NSC）赞助的小鼠研究产生了巨大的 大量数据，包括表型、遗传、表观遗传、表达谱和微生物组谱数据。 我们使用协作杂交（CC）近交系和多样性远交（DO）小鼠对遗传多样性的关注需要 对数百只老鼠的分析。随着新的表型分析技术的不断发展， 数据收集和分析继续增长。因此，一个运行良好和有效的数据管理和 统计分析操作是必要的。JAX NSC数据和统计核心的总体目标是提供 为JAX NSC项目的数据管理、质量控制、分析和传播提供支持。的 数据和统计核心的具体目标是：目标1。开发和维护数据管理， 质量控制和分析基础设施来支持JAX NSC项目。我们将继续 开发这个系统来实现自动化的数据收集和质量控制程序， 试点项目和合作组合。目标二。传播JAX NSC数据和分析工具， 提供了更多的访问这些和其他数据资源有关的小鼠模型在老化研究。 这一目标将支持开发新的数据类型和基于网络的互动工具。我们将开采公众 来自小鼠研究的与衰老相关的转录谱数据库，以更新并与JAX集成 NSC数据。目标3。为老龄化研究社区提供研究设计和统计分析支持。 核心将与老龄化研究界的成员进行合作研究，以支持 在使用小鼠模型的衰老研究中广泛采用遗传多样性。本次活动将 与其他JAX NSC核心中的项目并行管理和跟踪，但重点是与 已经或计划生成自己的主要实验数据的合作者。数据和统计 核心是重要的，因为它将提供高效，全面和先进的管理，分析， 传播衰老小鼠研究产生的数据，重点是了解遗传因素， 是寿命和健康的基础。改进数据管理和质量控制方法， 积极推广以促进JAX NSC数据的使用，并更深入地参与合作项目， 加快老龄化研究步伐，提升核心对老年科学研究界的影响 并增加JAX NSC数据和其他资源的可见性。

DATA AND STATISTICAL CORE PROJECT SUMMARY Mouse studies sponsored by The Jackson Laboratory Nathan Shock Center (JAX NSC) produce an enormous amount of data, including phenotypic, genetic, epigenetic, expression profiling and microbiome profiling data. Our focus on genetic diversity using Collaborative Cross (CC) inbred and Diversity Outbred (DO) mice requires the analysis of hundreds of mice. With new phenotyping technologies constantly being developed, the scope of data collection and analysis continues to grow. Thus, a well-functioning and efficient data management and statistical analysis operation is necessary. The overall goal of the JAX NSC Data and Statistical Core is to provide support for the management, quality control, analysis, and dissemination of data for JAX NSC projects. The Specific Aims of the Data and Statistical Core are to: Aim 1. Develop and maintain the data management, quality control, and analysis infrastructure needed to support JAX NSC projects. We will continue to develop this system to implement automated data collection and quality control procedures for our growing portfolio of pilot projects and collaborations. Aim 2. Disseminate JAX NSC data and analytical tools to provide greater access to these and other data resources related to mouse models in aging research. This aim will support development of new data types and web-based interactive tools. We will mine public repositories for aging-related transcriptional profiling data from mouse studies to update and integrate with JAX NSC data. Aim 3. Provide study design and statistical analysis support for the aging research community. The Core will engage in collaborative research with members of the aging research community to support the broader adoption of genetic diversity in aging studies that use mouse models. This outreach activity will be managed and tracked in parallel with projects in the other JAX NSC Cores but with an emphasis on working with collaborators who have or who plan to generate their own primary experimental data. The Data and Statistical Core is significant because it will provide efficient, comprehensive and cutting-edge management, analysis, and dissemination of data generated from aging mouse studies focused on understanding the genetic factors that underlie lifespan and healthspan. Improved data management and quality control methods, greater emphasis on active outreach to promote use of JAX NSC data, and deeper engagement with collaborative projects, will accelerate the pace of aging research, enhance the impact of the Core on the geroscience research community and increase the visibility of the JAX NSC data and other resources.