Energy Balance Core

能量平衡核心由格雷格·莫顿执导，约书亚·泰勒担任副核心主任。 此核心的主要功能是为附属调查人员(AIS)提供最先进的资源，以 啮齿动物的综合代谢表型。能源平衡核心的具体目标是： 具体目标1：为认可机构提供先进的能源综合平衡资源 以及与营养和肥胖相关的啮齿动物模型的代谢表型。 EB核心提供对能量平衡参数的全面定量评估，包括间接 能量消耗归一化多元线性回归热量法测定人体组织成分 活体标本和活组织标本、步行活动、车轮运行活动和进食模式的能量摄入 分析。我们还提供视频监控服务和广泛的温度调节服务，包括连续 核心体温监测、热导计算、热梯度试验和测量 棕色脂肪组织和尾部温度-可以在任何环境温度下使用温度- 控制室。由于EB Core是西雅图地区这些服务的唯一提供商，UW NORC 在营养和肥胖研究界的生产力和科学进步方面发挥着关键作用。 具体目标2：建立一个确保向认可机构提供服务的组织结构 以及时、高效和具有成本效益方式，所有服务的质量控制都是例行公事 评估过了。 我们优化所提供的服务范围，并确保它们无缝匹配且不与服务重叠 通过其他UW计划和中心提供。确保及时及有效率地向认可机构提供服务 以这种方式，EB核心实施了简化的动物转移和处理程序；高度重视 技术熟练、训练有素的人员，具有管理技术要求苛刻的设备的丰富经验，以确保 一致性和质量控制；强大的领导力，在设计、性能、分析和 与营养和肥胖相关的啮齿动物代谢表型的解释。 具体目标3：开发与相关技术进步同步的新服务和 满足我们用户群不断变化的需求。 在过去的5年里，我们在我们的扩展菜单中融入了许多创新技术 提供的服务。我们得到了一个温跃层和温度控制的代谢室 生热研究并引入了测量导热系数的定量方法。此外, 我们将时间和资源投入到教学和培训活动中，包括我们的norc ais和更广泛的科学领域。 社区，包括能源支出数据的正常化以及举办研讨会和讲习班 与能量平衡的调节和间接量热仪的使用有关。

The Energy Balance Core is directed by Greg Morton, with Joshua Thaler serving as Associate Core Director. The primary function of this Core is to provide Affiliate Investigators (AIs) with state-of-the-art resources for comprehensive metabolic phenotyping of rodents. The Specific Aims for the Energy Balance Core are: Specific Aim 1: To provide AIs with a state-of-the-art resource for comprehensive energy balance and metabolic phenotyping of rodent models relevant to nutrition and obesity. The EB Core provides comprehensive quantitative assessment of energy balance parameters including indirect calorimetry with energy expenditure normalization by multiple linear regression, body and tissue composition on living and biopsied specimens, ambulatory activity, wheel running activity and energy intake with meal pattern analysis. We also offer video monitoring services and extensive thermoregulatory services including continuous core body temperature monitoring, calculation of thermal conductance, thermal gradient tests, and measures of brown adipose tissue and tail-temperature that can be performed at any ambient temperature using temperature- controlled chambers. As the EB Core is the sole provider of these services in the Seattle area, the UW NORC plays a critical role in the productivity and scientific advances of the nutrition and obesity research community. Specific Aim 2: To create an organizational structure that ensures that services are provided to AIs in a timely, efficient and cost-effective manner and that quality control for all services is routinely assessed. We optimize the scope of services offered and ensure that they fit seamlessly and without overlap with services offered via other UW programs and centers. To ensure services are provided to AIs in a timely and efficiency manner, the EB Core has implemented a streamlined process for animal transfers and handling; have highly skilled and trained personnel with extensive experience managing technically demanding equipment to ensure consistency and quality control; and strong leadership with expertise in the design, performance, analysis and interpretation of rodent metabolic phenotypes related to nutrition and obesity. Specific Aim 3: To develop new services that keep pace with relevant technological advances and address the evolving needs of our user base. Over the past 5 years, we have incorporated a number of innovative techniques into our expanded menu of offered services. We obtained a thermocline and temperature-controlled metabolic chambers for adaptive thermogenesis studies and introduced quantitative approaches to measure thermal conductance. In addition, we devote time and resources to teaching and training activities both to our NORC AIs and the broader scientific community, including normalization of energy expenditure data and the development of a seminar and workshop related to the regulation of energy homeostasis and use of indirect calorimetry equipment.