CORE CENTER FOR CLINICAL RESEACH IN TOTAL JOINT ARTHROPLASTY (CORE-TJA)

摘要--总体 全关节置换术(TJA)是美国最常见、发展最快的手术。确实有 目前有700多万美国人生活在人工关节中。尽管手术量很大，但 TJA程序、技术和相关干预措施的证据基础有限。许多外科手术 在TJA中采用的入路和植入技术是基于理论依据和有限的临床 证据。更广泛的TJA研究社区需要访问大型、高质量和丰富的数据源和 最先进的临床研究标准和信息技术，以克服方法学和 TJA手术和非手术干预研究中的实际挑战。梅奥的首要目标 全关节置换术临床研究核心中心(CORE-TJA)旨在促进创新， 方法严谨和跨学科的临床研究，将直接改善TJA护理和 结果。CORE-TJA将作为疾病(TJA)和主题中心提供共享 方法专长、教育和数据资源。CORE-TJA将利用大数据资源 TJA研究，提供流行病学、生物统计学、卫生服务方面的定制方法资源 研究和医疗信息学，并围绕一个综合核心建立协同互动(美国 联合更换登记处(简写为AJRR)。 CORE-TJA的具体目标是：(1)对CORE-TJA进行行政和科学监督 活动(行政核心)，(2)提供综合服务，访问大型数据库和新的 TJA(方法学核心)临床研究的分析方法；以及(3)满足 TJA研究界，并加强国家大规模观测和 使用国家登记数据(资源核心)进行的TJA干预研究。CORE-TJA将整合 在梅奥诊所长期和高度集中的临床研究环境中，因此 利用现有的专业知识和基础设施资源，包括临床和翻译中心 科学。将使用稳健的指标对所有核心-TJA活动进行评估，以确保持续的评估， 灵活性和改进，以应对TJA研究界最紧迫的需求。

ABSTRACT - OVERALL Total joint arthroplasty (TJA) is the most common and fastest growing surgery in the nation. There are currently more than 7 million Americans living with artificial joints. Despite the high surgery volume, the evidence base for TJA procedures, technologies and associated interventions are limited. Many surgical approaches and implant technologies in TJA are adopted based on theoretical grounds with limited clinical evidence. The wider TJA research community needs access to large, high quality and rich data sources and state-of-the-art clinical research standards and information technologies to overcome methodological and practical challenges in studies of surgical and nonsurgical interventions in TJA. The overarching goal of Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) is to facilitate innovative, methodologically rigorous and interdisciplinary clinical research that will directly improve TJA care and the outcomes. The CORE-TJA will serve as a disease (TJA) and theme-focused Center providing shared methodological expertise, education and data resources. The CORE-TJA will leverage big data resources for TJA research, provide customized methodology resources in epidemiology, biostatistics, health services research and medical informatics, and establish synergistic interactions around an integrated Core (American Joint Replacement Registry – AJRR). The Specific Aims of CORE-TJA are: (1) To provide administrative and scientific oversight of CORE-TJA activities (Administrative Core), (2) To provide integrated services, access to large databases and novel analytical methods for clinical research in TJA (Methodology Core); and (3) To meet the unique data needs of the TJA research community and to strengthen the national capacity for large-scale observational and interventional studies in TJA using national registry data (Resource Core). The CORE-TJA will be integrated within the long-standing and highly centralized clinical research environment of the Mayo Clinic, thereby leveraging existing expertise and infrastructure resources, including the Center for Clinical and Translational Science. All CORE-TJA activities will be evaluated using robust metrics to ensure continuous evaluation, flexibility and improvement in response to the most pressing needs of the TJA research community.