Cherenkov imaging of Total Skin Electron Therapy (TSET)

全皮肤电子疗法的切伦科夫成像(TSET) 摘要 全身皮肤电子放射治疗已被临床证明是有效的 真菌样肉芽肿。然而，由于设置定位的不确定性和潜在的患者移动 在全皮肤电子治疗(TSET)期间，给患者皮肤组织的剂量可能会偏离 剂量处方。切伦科夫来自组织的发射最近被证明，提供了一种 与皮肤组织的辐射传递相关的标测。通过时间选通来最佳地捕获信号 增强型摄像机，与线性加速器脉冲同步，允许拒绝大多数 背景灯，并提供每次高剂量放射治疗的实时视频 费率。切伦科夫成像的实现提供了一种很好的技术来检测 治疗中的异常，否则就不会被注意到。这项建议旨在推进 这项技术作为一种验证工具，通过临床试验来监测患者的日常治疗效果 对患者进行测试，并制定适当的校正，以应用于获取的信号以确保它 在记录所提供的皮肤剂量方面是定量准确的。三个最主要的因素， 它们改变了剂量和切伦科夫信号之间的线性，是对透视的修正 方向、组织曲率和组织光学属性。这些重要的修正被量化为 这项对TSET的试点研究是与DoseOptics LLC合作进行的，该公司开发了 切伦科夫成像技术用于辐射验证，以完善技术用于日常监测 辐射传输。我们将通过比较切伦科夫成像的剂量精度来比较 使用二极管、OSLD和闪烁体探测器在9个地点进行活体测量。此外，我们 将在TSE治疗中对已知组织光学特性的光学模体进行测量 条件和蒙特卡罗模拟研究对这三个修正因子进行了量化。我们还将 开发将从校正的切伦科夫图像获得的皮肤剂量覆盖到患者特定的皮肤剂量的技术 基于TSE治疗前获得的表面3D身体轮廓数据的表面解剖评估 每日TSE治疗的实际皮肤剂量分布。综上所述，这个项目将继续向前推进 几十年来最引人注目的放射成像系统。该项目的核心是 结合技术系统，在TSET的设置中测试实用程序。

Cherenkov imaging of Total Skin Electron Therapy (TSET) Abstract Whole-body skin electron radiotherapy has been clinically demonstrated to be effective to treat mycosis fungoides. However, due to setup positioning uncertainties and potential patient movements during total skin electron therapy (TSET), dose delivered to the patient skin tissue can deviate from dose prescription. Cherenkov emission from tissue has recently been demonstrated, providing a mapping related to the radiation delivery to skin tissue. The signal is optimally captured by time-gated intensified cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background room light, and providing real time video of each radiotherapy treatment with high dose rates. The implementation of Cherenkov imaging offers an excellent technology to detect abnormalities in the treatment, which would otherwise go unnoticed. This proposal seeks to advance this technology as a verification tool through a clinical trial to monitor the daily treatment delivery of TSET patients and develop proper corrections that can be applied to the acquired signal to ensure it is quantitatively accurate in documenting delivered skin dose. Three of the most dominant factors, which alter the linearity between dose and Cherenkov signal, are the corrections for perspective direction, tissue curvature, and tissue optical properties. These important corrections are quantified in this pilot study of TSET, in partnership with DoseOptics LLC, the company that developed the Cherenkov imaging technology for radiation verification, to perfect technology for daily monitoring of radiation delivery. We will compare the dosimetry accuracy of Cherenkov imaging by comparing measurements in-vivo at 9 locations using diode, OSLD, and Scintillator detectors. In addition, we will perform measurements in optical phantoms of known tissue optical properties at TSE treatment conditions and Monte-Carlo simulation studies to quantity the three correction factors. We will also develop techniques to overlay skin dose obtained from corrected Cherenkov image to patient-specific surface anatomy based on surface 3D body contour data obtained before TSE treatment to assess the actual skin dose distribution for daily TSE treatment. Taking together, this project will advance on the most compelling systems for radiotherapy imaging in decades. The core of the project is combined technology systems, testing the utility in the setting of TSET.