Functional otoscopy for non-invasive diagnosis of middle ear pathologies

描述（由申请人提供）：临床上越来越需要提高中耳病理的体内非侵入性诊断能力。为了满足这一需求，物理科学公司（PSI）与马萨诸塞州眼耳医院（MEEI）的Eaton Peabody实验室合作，将开发一种临床可行的耳镜成像系统，该系统将采用相敏光学相干断层扫描（OCT）来评估通过完整鼓膜的中耳三维结构和声致运动。第一阶段对人类尸体颞骨的台式测试将包括空间和时间稳定性的实证验证以及视野的优化。PSI/MEEI团队将构建一个台式样机，获取和分析初步数据，并继续开发成像硬件和软件控制。临床原型的开发是在第二阶段提出的，对选定的活体受试者和临床患者进行测试。

DESCRIPTION (provided by applicant): There is a growing clinical need for improving the non-invasive diagnostic capabilities of middle ear pathologies in vivo. To address this need, Physical Sciences Inc. (PSI), in collaboration with the Eaton Peabody Lab at the Massachusetts Eye and Ear Infirmary (MEEI), will develop a clinically viable otoscopic imaging system that will employ phase sensitive optical coherence tomography (OCT) to assess three- dimensional structure and sound-induced motion of the middle ear through the intact eardrum. Phase I bench-top testing on human cadaveric temporal bones will include empirical validation of spatial and temporal stability and optimization of the field of view. The PSI/MEEI team will construct a benchtop prototype, acquire and analyze, preliminary data, and continue the development of the imaging hardware and software control. The development of a clinical prototype is proposed in Phase II with tests on selected live subjects and clinic patients.