Multi-Disciplinary Training Program in Translational Cardiovascular Research

该计划旨在培养能够开发新进展的博士后医生和科学家 在多学科的转化心血管研究，针对诊断，治疗和 预防心血管疾病（CVD）。在世界范围内，CVD是发病率和死亡率的主要原因 对于那些>30岁的人;不幸的是，在美国，经过多年的下降，CVD的发病率现在正在增加， 普遍性。该计划将有助于解决MD和PhD研究人员数量不足的问题（a NHLBI工作组对研究培训和职业发展计划的审查确认了短缺） 在多学科CVD研究活动中接受过培训，这些研究活动是寻求解决方案以减轻 CVD。我们的5年计划包括对4名医学博士申请人进行为期2年的培训，从PGY 5级开始， 和3名博士申请人3年从PGY 0级开始。该计划建立在研究实力， 弗吉尼亚联邦大学（VCU），涉及基础和临床转化CV科学， 小动物、单中心和多中心群体队列和临床试验。本建议的主要特点 T32培训计划包括：1）将每个受训者与外部资助的研究导师配对， 研究重点是CVD; 2）优秀的多学科教师谁是在培养年轻的经验 研究人员，并可以迅速建立这个T32计划，以促进学术上的成功进展， 医学; 3）从NIH资助的主要基础科学中获得多种表型和生物材料， 前瞻性队列，或通过支持计划教师在VCU的临床试验; 4）由 现有的研究生院和医学院，补充了以前没有经历过的简历研究领域 5）两个机构研讨会计划，加强来自 多学科。拟议的培训计划包括来自7个部门的15名教师;这些教师 目前指导11名符合方案资格标准的个人。每个人都有NIH或VA的校外 资金;以财政资源、设施和设备的形式提供强有力的机构支持; 与VCU健康差异中心整合，以招募和培训少数民族科学家;并支持 主要的专业发展活动，如演讲和赠款和手稿写作。的 T32培训计划的最终目标是吸引和培养一批优秀的学术科学家 精通CV多学科翻译研究的最新发展，然后将其应用于 设计和领导未来关于心血管健康重要问题的研究。的 拟议的培训计划，重点是培训MD和博士研究人员，将 增加医生和科学家的供应，能够开发多方面的新进展， 针对治疗和预防的学科转化心血管研究 心血管疾病是一个重大的公共卫生问题。

This program is designed to train post-doctoral physicians and scientists capable of developing new advances in multi-disciplinary translational cardiovascular research directed toward the diagnosis, treatment and prevention of cardiovascular disease (CVD). Worldwide, CVD is the primary cause of morbidity and mortality for those >30 years in age; unfortunately in the US after years of decline, rates of CVD are now increasing in prevalence. This program will help to address the inadequate number of MD and PhD investigators (a shortage recognized by the NHLBI task force review of research training and career development programs) trained in multi-disciplinary CVD research activities that are needed to pursue solutions to reduce the burden of CVD. Our 5-year proposal includes the training of 4 MD applicants for 2 years beginning at the PGY 5 level, and 3 PhD applicants for 3 years beginning at the PGY 0 level. The program builds on research strengths at Virginia Commonwealth University (VCU) involving basic and clinical translational CV science using cellular, small animal, and single and multi-center population cohort and clinical trials. Key features of this proposed T32 training program include: 1) pairing each trainee with an externally funded research mentor whose research focuses on CVD; 2) outstanding multidisciplinary faculty who are experienced in training young investigators and can quickly establish this T32 program for fostering successful progress in academic medicine; 3) access to multiple phenotypic and biologic materials from major NIH-funded basic science, prospective cohort, or clinical trials at VCU through the supporting program faculty; 4) courses provided by the existing graduate school and medical faculty that supplement areas of CV research not previously experienced by trainees; and 5) two institutional seminar programs that enhances interaction among individuals from multiple disciplines. The proposed training program includes 15 faculty from 7 departments; these faculty currently mentor 11 individuals who meet the program eligibility criteria. Each has NIH or VA extramural funding; strong institutional support in the form of financial resources, facilities, and equipment; robust integration with the VCU Center of Health Disparities for recruiting and training minority scientists; and support for key professional development activities such as presentations and grant and manuscript writing. The ultimate goal of this T32 training program is to attract and train a cohort of outstanding academic scientists fluent in the latest developments of CV multidisciplinary translational research, who will then apply this knowledge to design and lead future studies regarding important questions in cardiovascular health. The proposed training program, with an emphasis on training both MD and PhD investigators, would augment the supply of physicians and scientists capable of developing new advances in multi- disciplinary translational cardiovascular research directed toward the treatment and prevention of cardiovascular disease, a major public health issue.