Training in Host-pathogens interactions

描述(由申请者提供)：我们正在寻求支持，在五年的时间里培训寄主-病原体相互作用领域的研究生。马里兰大学5个学院的17名研究人员，他们的主要研究兴趣与宿主与病原体的相互作用有关，在化学与生命科学学院新成立的BISI研究生项目中，他们聚集在一起组成了一个研究集群。结核病、脑膜炎、利什曼病、流感和其他寄生虫感染等病原体引起的传染病的破坏性影响是众所周知的，从世界卫生的角度来看，理解微生物发病机制的努力很容易得到证明。微生物病原体的重要性远远超出了它们引起的疾病，因为研究它们的发病机制将在免疫学和细胞生物学方面带来新的见解。因此，这是研究生培训的绝佳领域。这项培训计划寻求支持一项独特的培训计划，该计划将使学生沉浸在跨学科研究中，努力将基因组学、免疫学和微生物发病机制方面的进展与我们对宿主-病原体相互作用的迅速扩大的了解结合起来。这个项目的目标是培训研究生在宿主-病原体相互作用的基础细胞和分子生物学方面的知识，着眼于开发翻译方法来改善健康。 相关性(见说明)：病原体感染几乎所有的生命形式，许多有可能引起世界范围的大流行。这项培训建议寻求支持，以培训博士前学生，以应对这些疾病可能带来的研究挑战。不同的教员将带来各种专业知识来处理研究宿主-病原体相互作用的常见问题。该计划包括制定保护人类和动物的战略，以提高人们的生活质量。

DESCRIPTION (provided by applicant): We are seeking support to train graduate students over a five year period in the area of host-pathogen interactions. Seventeen investigators in 5 colleges at the University of Maryland whose primary research interest pertains to host-pathogen interactions have come together to form a research cluster in the newly- formed BISI graduate program in the College of Chemical and Life Sciences. The devastating effects of infectious diseases caused by pathogens such as tuberculosis, meningitis, leishmaniasis, influenza and other parasitic infections, etc. are well known, and efforts to understand the mechanisms of microbial pathogenesis are easily justified from a world health perspective. The importance of microbial pathogens extends well beyond the diseases they cause, because studying their pathogenesis will lead to new insights in immunology and cellular biology. Thus, this is an excellent area for graduate student training. This training proposal seeks support for a unique training program that will immerse students in interdisciplinary research, striving to integrate advances in genomics, immunology, and microbial pathogenesis with our rapidly expanding understanding of host-pathogen interactions. The goal of this program is to train graduate students in basic cell and molecular biology of host-pathogen interactions, with an eye to developing translational approaches to improve health. RELEVANCE (See instructions): Pathogens infect nearly all life forms and many have the potential to cause world-wide pandemics. This training proposal seeks support to train predoctoral students to meet the research challenges that these diseases are likely to create. The diverse faculty will bring a variety of expertise to bear on problems that are common to studying host-pathogen interactions. This program includes developing strategies to protect humans and animals to improve the quality of people's lives.