Acquisition of an ITC200 isothermal titration calorimeter for Univ. of Notre Dame

描述(申请人提供)：请提供资金购买新一代，高灵敏度等温滴定量热计。这款仪器将取代目前校园里的旧型号。新仪器的一个主要好处是需要更小的反应体积，从而减少材料。较低的样品要求将允许那些目前正在进行热量测量的研究人员扩大他们的研究范围，并降低那些对热力学数量和热量测量感兴趣但因现有仪器的大样品要求而受阻的研究人员的准入门槛。将特别受益的研究人员包括那些研究难以大量获得的蛋白质和/或研究涉及通过合成有机化学制备的分子的相互作用的人。该仪器将被放置在一个配备了工作人员的核心设施中，以确保其长期的运营成功。

DESCRIPTION (provided by applicant): Funds are requested to purchase a new generation, highly sensitive isothermal titration calorimeter. This instrument will replace older models currently on campus. A major benefit of the new instrument will be the requirement for smaller reaction volumes and thus less material. The lower sample requirements will permit those investigators currently performing calorimetry to expand their studies, and lower the entry barrier for those investigators interested in thermodynamic quantities and calorimetry but hindered by the large sample requirements of the instruments presently available. Investigators who will particularly benefit include those studying proteins difficult to obtain in large quantities and/or studying interactions involving molecules prepared via synthetic organic chemistry. The instrument will be placed in a staffed core facility, ensuring its long term operational success.