Nicotinamide adenine dinucleotide (NAD+)-raising agents for improving oocyte quality

许多女性因为卵子质量不佳而无法生育，这通常是由于年龄的原因。目前，唯一的选择是使用另一名女性捐赠的质量更好的卵子。该项目将使用药理学试剂来促进最近在鸡蛋中发现的决定质量的关键途径。重要的是，我们将研究一种简单而实用的方法，可以用于临床，以增强这些途径，以提高卵子质量首次。

Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.