University of California Health Participation in the National COVID Cohort Collaborative (N3C)

项目总结 通过这份补充材料，我们将在加州大学的五个CTSA中心协调共同努力 加州(UC)健康公司将向国家COVID队列贡献数据并成为其战略合作伙伴 协作型(N3C)。通过将旧金山加州大学戴维斯分校的数据资源和研究信息学专业知识结合起来 在旧金山、洛杉矶、欧文和圣地亚哥，UC Health具有独特的优势，可以提供高质量的临床 加利福尼亚州不同患者群体的数据，以帮助N3C完成其使命，即 研究界可以用来研究和识别新冠肺炎的集中式国家数据资源 随着大流行的继续发展，可能的治疗方法也在不断发展。拟议的工作将利用现有的UC- 关于管理加州大学COVID研究数据集(UC CORDS)的广泛倡议，这是一个不断更新的HIPAA 有限的数据集，包含在任何时间进行新冠肺炎测试的所有患者的全面临床信息 加州大学健康中心。为了确保高质量和及时的数据交付，我们将创建统一通信范围的治理 结构以代表所有五个UC与NCATS建立主数据传输和使用协议(DTUA) CTSA中心，除了协调研究伦理审查。我们还将成立一个信息学特别工作组 让每个UC CTSA中心的关键利益相关者参与协调现场级数据工作。数据聚合、质量 保证和提交将由该中心的UC Health Data Warehouse(UCHDW)团队执行 加州大学校长办公室的数据驱动洞察和创新(CDI2)。 词汇表 发挥临床试验的作用 CDI2数据驱动的洞察和创新 CDW临床数据仓库 CMBI生物医学信息学中心 新冠肺炎冠状病毒病2019(新冠肺炎) CTSA临床和翻译科学奖 DTUA数据传输和使用协议 电子病历 集成生物学和床边的i2b2信息学 N3C国家COVID队列协作 OMOP观察性医疗结果伙伴关系 PCORnet全国以患者为中心的临床研究 网络 神社共享卫生研究信息网 加州大学布拉德分校生物医学研究 加速、集成和发展 加州大学科尔斯分校COVID研究 数据集 加州大学戴维斯分校戴维斯临床分校 和翻译科学中心 加州大学欧文ICTS大学欧文研究所 临床与转化学 加州大学雷克斯分校研究交流中心 UCHDW加州大学健康数据仓库 加州大学洛杉矶分校CTSI临床分校 和翻译科学研究所 加州大学圣地亚哥分校ACTRI圣地亚哥分校 临床与翻译研究所 加州大学旧金山分校CTSI分校 临床与翻译科学研究所

PROJECT SUMMARY Through this supplement, we will orchestrate a collective effort across the five CTSA Hubs at the University of California (UC) Health to contribute data to, and become a strategic partner of, the National COVID Cohort Collaborative (N3C). By combining the data resources and research informatics expertise at UC Davis, San Francisco, Los Angeles, Irvine, and San Diego, UC Health is uniquely positioned to provide high-quality clinical data of diverse patient populations across the State of California to help N3C fulfill its mission to “build a centralized national data resource that the research community can use to study COVID-19 and identify potential treatments as the pandemic continues to evolve.” The proposed work will leverage an existing UC- wide initiative on curating the UC COVID Research Data Set (UC CORDS), a continuously updated HIPAA Limited Data Set that contains comprehensive clinical information of all patients tested for COVID-19 at any UC Health facility. To ensure high-quality and timely data delivery, we will create a UC-wide governance structure to establish a master Data Transfer and Use Agreement (DTUA) with NCATS on behalf of all five UC CTSA Hubs, in addition to coordinating research ethics reviews. We will also create an informatics task force involving key stakeholders at each UC CTSA Hub to coordinate site-level data work. Data aggregation, quality assurance, and submission will be performed by the UC Health Data Warehouse (UCHDW) team at the Center for Data-Driven Insights and Innovation (CDI2) in the UC Office of the President. Glossary ACT Accrual to Clinical Trials CDI2 Data-Driven Insights and Innovation CDW Clinical Data Warehouse CMBI Center for Biomedical Informatics COVID-19 Coronavirus Disease 2019 (COVID-19) CTSA Clinical and Translational Science Awards DTUA Data Transfer and Use Agreement EHR Electronic health records i2b2 Informatics for Integrating Biology and the Bedside N3C National COVID Cohort Collaborative OMOP Observational Medical Outcomes Partnership PCORnet National Patient-Centered Clinical Research Network SHRINE Shared Health Research Information Network UC BRAID University of California Biomedical Research Acceleration, Integration, and Development UC CORDS University of California COVID Research Data Set UC Davis CTSC University of California, Davis Clinical and Translational Science Center UC Irvine ICTS University of California, Irvine Institute for Clinical and Translational Science UC ReX University of California Research Exchange UCHDW University of California Health Data Warehouse UCLA CTSI University of California, Los Angeles Clinical and Translational Science Institute UCSD ACTRI University of California, San Diego Altman Clinical and Translational Research Institute UCSF CTSI University of California, San Francisco Clinical and Translational Science Institute