Non-Alzheimer’s disease degenerative dementias: Identifying prodromal genetic/familial phenotypes, modifying factors, and protein variations involved in progression

这一建议将产生新的知识，为推进非阿尔茨海默病痴呆症的诊断。我们将使用与那些成功用于阿尔茨海默病诊断的方法相似的方法来识别额颞叶痴呆和路易体痴呆的临床前形式。重要的是，我们的团队有能力将这些方案转化为临床实践，并进一步提高生物学知识，这对未来的治疗靶向是必要的

This proposal will generate new knowledge necessary for advancing the diagnosis of the non-Alzheimer’s disease dementias. We will identify the preclinical forms of frontotemporal dementia and Lewy body dementia using similar methods to those successfully employed to advance diagnosis of Alzheimer’s disease. Importantly, our team has the capacity to translate these protocols into clinical practice and into further advances in biological knowledge that is necessary for future therapeutic targeting