Southwest Health Equity Research Collaborative

项目摘要 SHERC的总体目标是增加NAU的基础生物医学，临床和行为研究， 解决美国西南部不同人群之间的健康差距。在最初的5年里， 我们将加强环境和社区卫生领域的研究能力， 研究基地。随着时间的推移，SHERC将与社区合作伙伴密切合作，扩大能力， 解决慢性病和传染病以及高度优先的行为健康方面的健康差距 条件，由社区合作伙伴决定。SHERC由五个核心组成，它们都协同作用。 每一个SHERC核心都为单独的创新提供了明确的机会;结合起来， 在创新中发挥重要作用。行政核心结合了基于证据的 组织理论与测试，但新的使用“持续改进”模式的计划评估 和反馈。研究基础设施核心将侧重于SHERC的基础设施改进 基础研究、信息学、临床和社区参与的科学计划。此外，还需要一个 在改善生物医学、临床和社区卫生领域的跨学科科学工作方面发挥领导作用 科学研究在全国范围内。研究者发展核心将支持早期 职业调查员在基础生物医学，行为和临床科学在NAU通过两个创新的 计划：一个试点项目计划（PPP），以支持教师和博士后学者计划（PSP）， 支持和指导博士后研究人员。社区参与核心采用创新的四个- 调查和行动框架，将代表健康的共同和独特的决定因素， 亚利桑那这五个研究项目包括以下创新研究： 定义和对比S。金黄色葡萄球菌携带和循环基因型与临床基因型和感染 流行率，以更好地了解社会互动如何影响传播。Kellar和Propper试图 加强目前对环境污染物与临床并发症之间关系的研究 例如不愈合的慢性伤口。Varadaraj的研究将利用肿瘤中的细胞适应， 确定在这种状态下改变纤维形成是否会将癌前细胞转变为恶性细胞， 前侵袭性细胞是否会变成侵袭性细胞纳伦的研究有可能改善和扩展 基于呼肠孤病毒的癌症疗法。Fofonav的研究可能会识别出口腔微生物组更多的个体。 易患幼儿龋（ECC）或携带特别致病的S.变形菌和 S. sobrinus。

PROJECT SUMMARY The overall goal of SHERC is to increase basic biomedical, clinical, and behavioral research at NAU to address health disparities among diverse populations of the Southwestern United States. In the first 5 years, we will increase research capacity in the areas of environmental and community health, building on a strong research base at NAU. Over time, SHERC will work closely with community partners to expand capacity to address health disparities in chronic and infectious diseases, as well as high-priority behavioral health conditions, as determined by community partners. SHERC consists of five cores that all interact synergistically. Each of the SHERC cores provides a clear opportunity for innovation individually; in combination, they demonstrate significant impact in innovation. The Administrative Core combines evidence-based organizational theory with a tested but novel use of a “continuous improvement” model of program assessment and feedback. The Research Infrastructure Core will focus on infrastructure improvement for the SHERC basic research, informatics, clinical, and community engaged science programs. In addition, it will take a leadership role in improving the interdisciplinary science efforts in biomedical, clinical, and community health science initiatives throughout NAU. The Investigator Development Core will support the development of early career investigators in basic biomedical, behavioral, and clinical sciences at NAU through two innovative programs: a Pilot Project Program (PPP) to support faculty and a Postdoctoral Scholar Program (PSP) to support and mentor postdoctoral researchers. The Community Engagement Core uses an innovative four- direction Framework for Inquiry and Action that will represent the shared and distinct determinants of health in Arizona. The five Research Projects include the following innovative studies: Pearson's research project will define and contrast S. aureus carriage and circulating genotypes with clinical genotypes and infection prevalence to better understand how social interactions impact transmission. Kellar and Propper seek to enhance current research on the relationship between environmental contaminants and clinical complications such as non-healing chronic wounds. The Varadaraj study will exploit a cellular adaptation in tumors, to determine whether altering fibrillogenesis in such states will switch premalignant cells to malignant cells and whether preinvasive cells would become invasive. Naren's study has the potential to improve and extend reovirus based cancer therapies. Fofonav's study may identify individuals with an oral microbiome that is more susceptible to early childhood caries (ECC) or individuals with particularly pathogenic strains of S. mutans and S. sobrinus.