Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini

项目概要/摘要 与斯威士兰大学和斯威士兰卫生部合作（包括国家艾滋病毒和艾滋病预防中心）， 贝勒医学院（Baylor College of Medicine）将开展艾滋病毒/艾滋病研究方法的培训， 重点关注儿科和结核病（TB）共病。其他主要合作伙伴包括德克萨斯大学 公共卫生学院（UTHealth SPH）将在公共卫生期间支持和指导长期学员 硕士和博士水平的研究。我们的艾滋病毒/结核病合作培训计划将培训i）三名博士生 候选人将成为独立研究者，从事以艾滋病毒/结核病为重点的临床和转化研究， 儿科（婴儿、儿童和青少年）人群，以及ii）两个国内公共卫生受训人员队列 成为儿童健康研究的助理研究员培训利用了一种新颖的斯威士兰-美国双重 指导战略，以确保保留，成功，并由美国长期进行的研究的相关性 Siyakhula学者。长期Siyakhula学者将在UTHealth SPH注册，以获得博士学位或博士学位， 在斯威士兰开展论文活动，吸引国内Siyakhula学者和导师。我们将雇用一名 “反馈”方法，即长期受训人员参加设在斯威士兰的培训论坛， 教学技能，并加强与国内学者的伙伴关系。我们的目标是加强临床研究 能力在斯威士兰，同时产生高质量的研究人员谁将成功过渡到 独立，获得独立的资金，并领导国家努力结束艾滋病毒/结核病的流行，现在是领先的 传染病是全球死亡的主要原因。我们制定了一项培训计划，以适应今天的艾滋病毒 研究优先事项适当地侧重于结核病特异性科摩罗，同时与斯威士兰保持一致 美国国家卫生研究院和福格蒂国际中心的国家研究战略和优先事项。在我们过去的基础上 成功，我们将在四个重要的计划领域培训下一代艾滋病毒科学家， 流行病学、生物统计学和生物信息学、行为科学和健康促进以及卫生系统 管理和政策。我们将在这些多学科临床基础上发展能力， 通过实现以下具体目标进行转化研究：1）利用现有的儿科艾滋病毒 提供专业知识，以加强对艾滋病毒/结核病合并感染儿童的调查，并提供长期培训， 独立的Emaswati调查员在流行病学，生物统计学和 生物信息学，行为科学与健康促进，卫生系统管理与政策; 2）提供 为来自以下国家的合格的Siyakhula学者提供儿童健康应用研究方法的国内强化培训： 斯威士兰的伙伴机构; 3）支持当地的研究基础设施和现有的研究界 同时丰富环境和能力，以支持未来健康的教育研究机会， 专业人士

Program Summary/Abstract In collaboration with the University of Eswatini and the Eswatini Ministry of Health (including national HIV and TB programs), Baylor College of Medicine (BCM) will conduct training in HIV/AIDS research methods with a focus on pediatrics and Tuberculosis (TB) co-morbidity. Other key partners include The University of Texas School of Public Health (UTHealth SPH) who will support and mentor long-term trainees during Public Health Masters and Doctoral level studies. Our collaborative HIV/TB training program will train i) three doctoral candidates to become Independent Investigators in clinical and translational research focusing on HIV/TB in pediatric (infants, children, and adolescents) populations, and ii) two in-country cohorts of public health trainees to become Associate Investigators in child health research. The training capitalizes on a novel Eswatini-US dual mentoring strategy to ensure retention, success, and relevance of research conducted by US-based long-term Siyakhula Scholars. Long-term Siyakhula Scholars will enroll in UTHealth SPH to earn a PhD or DrPH and conduct thesis activities in Eswatini engaging in-country Siyakhula Scholars and mentors. We will employ a "teach-back" approach in which the long-term trainees participate in Eswatini-based training forums to develop teaching skills and strengthen partnerships with in-country scholars. Our goal is to strengthen clinical research capacity in Eswatini while simultaneously producing high-quality researchers who will successfully transition to independence, obtain independent funding and lead national efforts to end the HIV/TB epidemic, now the leading infectious causes of mortality globally. We have developed a training plan that has adapted to today's HIV research priorities appropriately focused on TB specific comorbidity while being aligned with the Eswatini National Research Strategy and priorities of the US NIH and Fogarty International Center. Building on our past successes, we will train the next generation of HIV scientists in four essential programmatic areas including epidemiology, biostatistics and bio-informatics, behavioral science and health promotion, and health systems management and policy. We will develop capacity in these cornerstones of multidisciplinary clinical and translational research by accomplishing the following specific aims: 1) Capitalize on existing pediatric HIV expertise to enhance investigation of HIV/TB co-affected children and provide long-term training to produce Independent Emaswati Investigators in the most recent advances in the fields of epidemiology, biostatistics & bio-informatics, behavioral science & health promotion, and health systems management & policy; 2) Provide intensive in-country training in Child Health Applied Research Methods to well-qualified Siyakhula Scholars from partner institutions in Eswatini; 3) Support local research infrastructure and the existing research community while enriching the environment and capacity to support educational research opportunities for future health professionals.