Deriving a de novo adolescent addiction treatment from developmental brain data

项目摘要 博士费尔德斯坦·尤因正在申请职业中期研究者奖（K24），以支持她的发展， 创新，转化（临床+成像）研究在青少年酒精治疗。K24将保护 有时间让她指导新出现的调查人员。她的职业发展和培训目标是 与预先规划的研究目标紧密地、协同地联系在一起。Feldstein Ewing博士的5-10年研究 该计划是为青少年成瘾者开发更有效的治疗方法。费尔德斯坦·尤因博士 认为这一领域的进步最有可能源于直接质疑的综合方法， 发展中的大脑，并旨在量身定制明确的干预措施，以应对这一非常具体的时期， 神经发育的过程。青少年成瘾的转化研究是非常劳动密集型的。K24研究 资金是必要的，以提供博士费尔德斯坦尤因与保护的时间从临床和 行政职责，在这种类型的医院/医疗护理环境中，通常是高度时间密集型的，但 不幸的是，这并不能促进研究、培训或指导。因此，受保护的时间内， 这一机制将有助于提供必要的保护范围，使调查人员能够 了解更多关于青少年心理病理学，青少年学习和 记忆，和先进的定量方法，可用于最大限度地利用现有的数据，候选人 在为高需求青少年开发新的干预措施方面， 与毒瘾作斗争这种保护也将有助于费尔德斯坦·尤因博士在受保护的时间内从事 并让学员参与到这个过程的每一个阶段。与许多其他学术医疗培训中心一样， 如果没有K24，费尔德斯坦博士将无法获得这种受保护的研究/培训时间 尤因这一覆盖范围对于推进青少年治疗创新至关重要， 我们有资源和机会进行这项工作。这是一个高度关注和需要的领域 对于NIAAA;这个K24奖将启动一个新的科学家领域，开始在这一领域的真正进展， 青少年酒精和成瘾研究及其干预。

PROJECT SUMMARY Dr. Feldstein Ewing is applying for a Mid-Career Investigator Award (K24) to support her development of innovative, translational (clinical + imaging) research in adolescent alcohol treatment. The K24 would protect time to facilitate her mentorship of emerging investigators. Her career development and training aims are tightly and synergistically linked to advance planned research aims. Dr. Feldstein Ewing's 5-10 year research plan is to develop more efficacious treatment for adolescents who struggle with addiction. Dr. Feldstein Ewing believes that advances from this area are most likely to stem from integrative approaches that directly query the developing brain, and aims to tailor articulated interventions that are responsive to that very specific period of neural development. Translational research in adolescent addiction is very labor intensive. K24 research funding is requisite to provide Dr. Feldstein Ewing with protected time from the call of clinical and administrative duties, which in this type of hospital/medical care setting are often highly time intensive, but unfortunately do not advance research, training, or mentorship. Thus, protected time available within this mechanism would facilitate precisely the type of protected coverage requisite for freeing up the investigator to learn more about existing interventions in the field of adolescent psychopathology, adolescent learning and memory, and advanced quantitative methods that can be used to maximize existing data that the candidate already has, to propel the field forward in terms of developing novel interventions for high-need adolescents struggling with addiction. This protection would also facilitate protected time for Dr. Feldstein Ewing to engage and involve mentees at every stage of this process. As with many other academic medical training centers, without this K24, this type of protected research/training time will not otherwise be available to Dr. Feldstein Ewing. This coverage is crucial for advancing innovations in adolescent treatment, at a critical juncture where the resources and opportunity are available for this work to be done. This is a high area of interest and need for NIAAA; this K24 award would launch a new field of scientists to start true progress in this domain of adolescent alcohol and addiction research, and its intervention.