Administrative Core

项目总结/摘要 修订后的COBRE应用免疫学和病理过程中心的目标是 建立国家认可的先进研究和培训计划，促进发展 初级教员的研究转向主要独立研究经费之间的研究交叉 免疫反应和疾病发病机制的功能障碍。也就是说，我们希望应用 免疫学作为一门学科在校园里，因为它的重要性，作为一个基础科学，临床科学和 转化科学，可以从事和协同与校园内的所有其他中心。我们特别 希望能专注于了解异常免疫反应与疾病的发病机制， 更好地了解当免疫反应改变时，免疫病理学或疾病 发展环境这一重点研究领域符合我们目前的专业知识和我们的新 有针对性的初级教师招聘计划（2019年已聘请了3名新的终身教职教师，这些教师直接适合 COBRE申请; 2020年将开设更多职位）。为了实现这一目标， 研究计划发展沿着指导和培训是必需的。政府当局 核心A将实施和管理所有的COBRE计划倡议，包括建立先进的研究 核心设施，建立初级教师发展导师计划，初级教师发展 讲习班，建立外部和内部咨询委员会，沿着有一名高级指导 委员会，与外部研究专家协调，设立年度科学座谈会 和正式的评估程序，并建立试点赠款机制， 有前途的项目管理核心（核心A）将由COBRE PI管理 沿着协调员协助、核心管理协助和 方案预算。该核心将集中所有COBRE计划文档和报告， 符合NIH COBRE要求。

PROJECT SUMMARY/ABSTRACT The goal of the revised COBRE Center for Applied Immunology and Pathological Processes is to establish a nationally recognized advanced research and training program that facilitates the development of junior faculty research toward major independent research funding in the research intersections between the dysfunctioning of the immune response and disease pathogenesis. That is, we hope to grow Applied Immunology as a discipline on campus because of its importance as a basic science, clinical science and a translational science that can engage and synergize with all of the other centers on campus. Specifically, we hope to focus on the understanding of abnormal immune responses with disease pathogenesis, such that we provide a better understanding of how when the immune response is altered, immunopathology or disease development ensues. This focused research area is in line with our current expertise and with our new targeted junior faculty hiring plan (3 new tenure track faculty have been hired in 2019 that fit directly with the COBRE application; additional positions will open in 2020). In order to accomplish this goal, a multifaceted plan for research program development along with mentorship and training is required. The Administration Core A will implement and manage all COBRE program initiatives including establishing advanced research core facilities, establishing a mentorship program for junior faculty development, junior faculty development workshops, establishing External and Internal Advisory Committees along with a Senior Mentoring Committee, coordination with the External Research Specialists, establishing an annual scientific colloquium and formal evaluation procedures, and establishing pilot grant mechanism that supports development of promising projects from junior faculty. The Administration Core (Core A) will be managed by the COBRE PI along with coordinator assistance, core management assistance, and business management oversight of the program budget. This core will centralize all COBRE program documentation and reporting in compliance with NIH COBRE requirements.