The UNC Chapel Hill Superfund Research Program (UNC-SRP)

摘要：UNC-Chapel Hill超级基金研究项目 查佩尔山的北卡罗来纳州大学跨学科超级基金研究计划（UNC-SRP） 将解决北卡罗来纳州和全国各地社区面临的严重公共卫生挑战 无机砷（iAs）UNC-SRP优先考虑iAs作为重点污染物，因为它具有高度相关性 数百万人在北卡罗来纳州和美国暴露在不安全的水平。在北卡罗来纳州，污染来源于两个地质成因 污染源和工业活动（如超级基金场地和煤灰污染）污染了数千个私人 威尔斯。据估计，北卡罗来纳州约有300万人，占该州人口的三分之一， 私人威尔斯井，iAs范围高达800 ppb。这些人口主要分布在NC的农村地区， 建立环境正义的条件。此外，iAs污染在全州范围内回荡， 地方和国家相关。与公共健康风险相关，已确定接触iAs 与代谢功能障碍/糖尿病相关。在对驱动因素的了解方面存在着重大差距 iAs诱发的糖尿病风险。这些因素的识别将有助于开发新的 降低iAs相关糖尿病以及其他相关疾病患病率的解决方案/干预措施 iAs曝光。我们独特的科学主题是“确定减少iAs暴露的新方法， 阐明iAs诱导的代谢功能障碍的潜在机制，并展望疾病 预防”。我们的研究目标有三：（1）发现生物学机制和易感因素 潜在的iAs相关代谢功能障碍/糖尿病;（2）开发新的方法和技术， 预测iAs污染并减少iAs暴露;（3）将UNC-SRP的科学转化为关键 在全国委员会和更大的SRP方案的利益攸关方，并参与弱势社区。UNC-SRP包括 五个研究项目。项目1-3使用跨越体外和体内模型的高度转化技术， 人类群体了解IA诱导的糖尿病的机制。项目4-5提高了预测能力 私人饮用威尔斯井中的iAs污染和增强iAs去除的创新方法。相关性 国家SRP计划，我们将与现场经理在费尔法克斯圣伍德超级基金网站。 五个核心包括行政核心、社区参与核心、数据管理和分析 核心（DMAC），研究经验和培训协调核心（RETCC），化学和分析 核心（CAC）。这些核心促进管理，社区参与与我们的合作伙伴清洁水， NC和Winyah Rivers基金会，数据管理和分析，培训和化学分析。总之， UNC-SRP使命是通过以下方式为减少流感和预防疾病制定新的解决方案 机械和转化研究，最终为监管和超级基金现场清理工作提供信息。

ABSTRACT: THE UNC-CHAPEL HILL SUPERFUND RESEARCH PROGRAM The interdisciplinary Superfund Research Program at the University of North Carolina at Chapel Hill (UNC-SRP) will address serious public health challenges faced by communities in North Carolina (NC) and across the nation related to inorganic arsenic (iAs). The UNC-SRP prioritizes iAs as the focus contaminant as it is highly relevant to millions in NC and the US exposed to unsafe levels. In NC, contamination is derived from both geogenic sources and industrial activities (e.g. superfund sites and coal ash contamination) polluting thousands of private wells. An estimated ~3 million individuals in NC, representing one third of the state’s population, drink water from private wells, with iAs ranging up to 800 ppb. These populations are largely located in the rural areas of NC with established environmental justice conditions. Moreover, iAs contamination reverberates across the state and is locally and nationally-relevant. Related to public health risk, exposure to iAs has been established to be associated with metabolic dysfunction/diabetes. There is a significant gap in the knowledge of factors that drive iAs-induced diabetes risk. The identification of these factors would facilitate development of novel solutions/interventions to reduce the prevalence of iAs-associated diabetes, as well as other diseases associated with iAs exposure. Our unique scientific theme is “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” We address this with three aims: (1) Discover biological mechanisms and susceptibility factors underlying iAs-associated metabolic dysfunction/diabetes; (2) Develop novel methods and technologies to predict iAs contamination and reduce iAs exposure; (3) Translate the science of the UNC-SRP to key stakeholders in NC and the larger SRP program, and engage vulnerable communities. The UNC-SRP comprises five research projects. Projects 1-3 use highly translational techniques spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and innovative methods for enhanced removal of iAs. With relevance to the national SRP program, we will work with site managers at the Fairfax St. Wood Treaters Superfund site. Five Cores include the Administrative Core, the Community Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training Coordination Core (RETCC), and Chemistry and Analysis Core (CAC). These Cores facilitate administration, community engagement with our partners Clean Water for NC and the Winyah Rivers Foundation, data management and analysis, training, and chemical analyses. In sum, the UNC-SRP mission is to develop new solutions for iAs reduction and disease prevention through mechanistic and translational research to ultimately inform regulation and Superfund site cleanup efforts.