Center of Comparative Medicine and Pathology

摘要 比较医学和病理学中心（CCMP）支持在癌症研究中使用动物模型 通过其研究动物资源中心（RARC）和比较病理学实验室（LCP）。在 MSK，动物模型用于基础和应用调查研究以及临床和实验室培训。 和研究人员。动物被用于不同的领域，包括开发新的方法， 诊断和治疗癌症以及阐明导致癌症的基本生物学机制， 肿瘤形成CCMP的专业和准专业人员（163 FTE）担任咨询和技术顾问， 为MSK研究人员提供与动物研究相关的所有事宜的资源。RARC包括五个部分：1） 水产系统和服务; 2）生物安全; 3）教育和质量保证（EQA）; 4）畜牧业和 （5）兽医服务（VS）。RARC为超过100万人提供住房和人道主义照顾， 每天170，000只动物，由122名研究者使用。RARC对MSK的AAALAC认证的监督， 管理动物护理计划确保有效利用可用空间和人员资源，并允许 对动物研究项目进行密切的专业监督。水产系统和服务维护 该公司的主要业务是为MSK的斑马鱼种群提供饲养和技术服务。 生物安全确保MSK的啮齿动物群落保持病原体免费定期调查殖民地的健康， 从商贩那里拦截啮齿动物。EQA管理着一个广泛的教育计划， 通过教学和实践课程、基于网络的教程以及 书面教学材料。RARC的H&O部门运营着两个专业的最先进的设施 占地约73，700平方英尺的空间，提供关键环境和专业 各种动物模型的维护和使用所必需的设备。VS的工作人员确保所有 动物接受适当的临床护理，并为研究人员执行技术程序。LCP，一种多- 学科病理学实验室及其遗传工程动物（GEA）表型分析服务，支持 通过提供临床和解剖病理学服务， 和广泛的GEA表型谱。

ABSTRACT The Center of Comparative Medicine and Pathology (CCMP) supports animal model use in cancer research through its Research Animal Resource Center (RARC) and Laboratory of Comparative Pathology (LCP). At MSK, animal models are used in basic and applied investigational studies as well as for training of both clinical and research staff. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer as well as the elucidation of the basic biological mechanisms resulting in neoplasia. CCMP’s professional and paraprofessional staff (163 FTE) serve as a consultative and technical resource for MSK investigators on all matters related to animal research. RARC comprises five sections: 1) Aquatic Systems and Services; 2) Biosecurity; 3) Education and Quality Assurance (EQA); 4) Husbandry and Operations (H&O); and, 5) Veterinary Services (VS). RARC provides housing for and humane care to over 170,000 animals daily, utilized by 122 investigators. RARC’s oversight of MSK’s AAALAC-accredited, centrally managed animal care program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the animal research program. Aquatic Systems and Services maintain the housing systems and provide husbandry and technical services in support of MSK’s zebrafish colonies. Biosecurity ensures that MSK’s rodent colonies remain pathogen free by routinely surveying colony health and quarantining incoming rodents from vendors. EQA administers an extensive educational program that provides training to animal care and research staff via didactic and hands-on sessions, web-based tutorials, as well as written instructional materials. RARC’s H&O section operates two specialized state-of-the-art facilities encompassing ~73,700 net square feet of space that provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. VS’s staff ensures that all animals receive appropriate clinical care and perform technical procedures for research staff. The LCP, a multi- disciplinary pathology laboratory, and its Genetically Engineered Animal (GEA) Phenotyping Service, support individual laboratory’s research and RARC’s programs by providing clinical and anatomic pathology services and extensive phenotypic profiles of GEA.