Chemical Mixtures Core

核心摘要--化学混合物核心 超级基金网站含有多种污染物的混合物。美国环保局关于实施的补充指导 化学品的健康风险评估指出，“基于全混合物的方法比 组件方法“。研究界需要健壮的、分析物丰富的方法，适合于复杂的 矩阵。科学界需要新的、专门的、更敏感的方法来分离、检测和 对数十种差异很大的多环芳烃(PAHs)和取代的PAHs进行定量 复杂、非均相基质中的浓度和化学性质。这些挑战继续存在 推动多环芳烃、取代多环芳烃和多环芳烃转化产物分析方法的发展，如 以及超级基金的共同污染物。环境和环境中的多环芳烃和x-多环芳烃的分析要求很高。 生物基质因为样品是复杂的，烷基化和高分子的众多异构体- 大量化合物往往很难区分，我们往往缺乏标准和适当的参考 材料。化学混合物核心(CMC)的主要目标是支持其他超级基金中心 项目和核心。我们将最大限度地让他们获得有质量保证的定量分析技术和 使他们能够增加他们的创造力和知识。我们将创造新的和改进的方法来 多环芳烃、多环芳烃代谢物和取代的多环芳烃(例如，烷基、氧和氮取代的多环芳烃)。我们会 与数据管理和分析核心(DMAC)合作，改进我们独特的基于Web的界面 用于索取标准、认证标准物质和提交样品。我们将发展和完善 我们的海量数据生产和管理平台。我们将通过以下方式扩展1,530个分析物筛选 继续发展用于混合物分析的简化论方法。我们将创造生物可利用的真实世界 来自Superfund土壤、沉积物和水提取物的参考材料与环境合作 并将这些材料提供给生物项目。我们将提供基于网络的培训材料，以 以调查人员和受训人员为中心的分析方法和生物分析技术。

CORE SUMMARY – CHEMICAL MIXTURES CORE Superfund sites contain mixtures of many contaminants. The US EPA Supplemental Guidance for Conducting Health Risk Assessments of Chemicals stated that “approaches based on whole mixtures are preferred to component approaches”. The research community needs robust, analyte-rich methods suitable for complex matrixes. The scientific community needs new, specialized, more sensitive methods to separate, detect, and quantify dozens of polycyclic aromatic hydrocarbons (PAHs) and substituted PAHs with widely varying concentrations and chemical properties in complex, heterogeneous matrices. These challenges continue to drive the development of analytical methods for PAHs, substituted PAHs and PAH transformation products, as well as Superfund co-contaminants. It is demanding to analyze PAHs and x-PAHs in environmental and biological matrices because the samples are complex, the numerous isomers of alkylated and high-molecular- mass compounds are often difficult to differentiate, and we often lack standards and suitable reference materials. The primary goal of the Chemistry Mixtures Core (CMC) is to support other Superfund Center projects and cores. We will maximize their access to quality-assured quantitative analytical technologies and empower them to increase their creativity and knowledge. We will create new and improved methods for PAHs, PAH metabolites, and substituted PAHs (e.g., alkyl-, oxygen- and nitrogen- substituted PAHs). We will collaborate with the Data Management and Analysis Core (DMAC) to improve our unique web-based interface for requesting standards, certified reference materials and submitting samples. We will develop and improve our high-volume data production and management platform. We will expand the 1,530-analyte screen by continuing to develop reductionist methods for mixture analysis. We will create bioavailable real-world reference materials from Superfund soil, sediment and water extracts in collaboration with the environmental projects and provide these materials to the biological projects. We will provide web-based training material for analytical methods and bio-analytical technologies to center investigators and trainees.