Greater Southern California Node of the Clinical Trials Network

项目总结/摘要 国家药物滥用预防中心大南加州节点（GSCN）的总体目标 治疗临床试验网络（CTN）是扩大获得和改善治疗的结果， 物质使用障碍（SUDs）-特别强调阿片类药物使用障碍（OUD）-通过合作 制定和测试有效和可持续的干预措施，以促进可持续发展， 医疗保健设置。为了实现这一目标，我们已经聚集了（1）地方，区域和全州范围的医疗保健 为数百万人服务的网络，（2）对发展进行开创性工作的调查人员 和药物和行为干预SUD的测试，和（3）研究人员与专业知识， 实施战略，数据科学和创新技术，以支持治疗提供和相关 research.在调查人员过去和目前努力的基础上，GSCN的具体目标是：目标1。铅 并为制定新的研究方案做出贡献， OUD和改善治疗结果;目标2。支持和参与多站点CTN项目及其他 CTN的活动;以及目标3。传播研究成果并提供创新培训，以影响临床 实践GSCN的研究议程最初将集中在四个优先领域：（1）开发和测试 对OUD和相关合并症进行有效的药物治疗和行为干预，（2）应用 实施科学，以在多种医疗保健环境中提供和扩展OUD治疗，（3）利用 电子健康（例如，电子健康记录系统）和数据科学，以发现和产生创新的 改善OUD治疗的假设和方法，以及（4）建立在移动健康（例如，智能手机- 辅助干预）和其他技术（例如，远程医疗）以扩大OUD治疗的可及性， 利用率GSCN的研究议程反映了其合作扩大CTN努力的能力， 并实施创新方法，以改善对OUD和其他SUD的治疗。

Project Summary/Abstract The overarching goal of the Greater Southern California Node (GSCN) of the National Drug Abuse Treatment Clinical Trials Network (CTN) is to expand access to and improve outcomes of treatments for substance use disorders (SUDs)—with a special emphasis on opioid use disorder (OUD) —by collaboratively developing and testing effective and sustainable interventions for OUD that can be delivered in diverse healthcare settings. To achieve this goal, we have assembled (1) local, regional, and state-wide healthcare networks that serve millions of individuals, (2) investigators who have conducted seminal work on development and testing of pharmacological and behavioral interventions for SUDs, and (3) researchers with expertise in implementation strategies, data science, and innovative technologies to support treatment delivery and related research. Building upon investigators' past and current efforts, the specific aims of GSCN are: Aim 1. Lead and contribute to the development of new research protocols designed to increase access to treatments for OUD and to improve treatment outcomes; Aim 2. Support and participate in multi-site CTN projects and other CTN activities; and Aim 3. Disseminate research findings and provide innovative training to impact clinical practice. The GSCN research agenda will initially focus on four priority areas: (1) developing and testing effective medication and behavioral interventions for OUD and related comorbidities, (2) applying implementation science to deliver and expand OUD treatment in multiple healthcare settings, (3) leveraging eHealth (e.g., electronic health record systems) and data science for discovery and generation of innovative hypotheses and approaches to improve treatment for OUD, and (4) building on mHealth (e.g., smartphone- assisted interventions) and other technologies (e.g., telemedicine) to expand OUD treatment access and utilization. The GSCN research agenda reflects its capacity to collaboratively expand CTN efforts to develop and implement innovative approaches to improve treatment for OUD and other SUDs.