Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

我们要求增加每年的直接费用，以支持MERIT延期的目标。我们 这一提议是对社会神经科学未来的一次戏剧性飞跃， 技术.拟议的研究是创新的，雄心勃勃的，并且对于理解灵长类动物和 通过扩展人类，大脑使真实的世界中适当的社会行为成为可能。我们的提议 了解灵长类动物的大脑如何通过一个紧密整合的，雄心勃勃的 一组4个特定目标，结合多个自由移动中的同时无线神经生理记录 猴子在不同的社会环境中自然互动，半自动到全自动量化社会行为 使用计算机视觉、药理学操作和神经活动的可逆扰动。对我们 据了解，这些实验都没有在猕猴身上尝试过。我们的飞行员数据令人信服地 证明我们可以做到。

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.