SARS-COV-2 Sequence Surveillance: Molecular Epidemiology, Clinical Correlations and Prospective Monitoring

项目总结：总体 路易斯安那州临床和转化科学(LA CATS)中心是由主要学术机构 以及路易斯安那州的生物医学研究中心。彭宁顿生物医学研究中心是领头羊 并将继续与路易斯安那州立大学健康(LSUH)-新奥尔良和杜兰-合作 大学健康科学中心参与了这一倡议。路易斯安那州立大学什里夫波特、路易斯安那州立大学(巴吞鲁日)、泽维尔 新奥尔良大学和儿童医院是第一周期的早期研究伙伴。 退伍军人医疗系统，新奥尔良新开设的大学医疗中心(州立大学10亿美元 投资)、Ochsner Health和LSUH-NO牙科学校在第二周期加入。洛杉矶CATS中心 正在为路易斯安那州建立一个统一的临床转化科学计划，该计划建立在Synergistic 所有主要学术和生物医学研究机构的计划和无与伦比的合作 州政府。自9年前成立以来，洛杉矶CATS中心已经：1)成功地利用资源和专业知识 多个参与机构建立充满活力的全州研究基础设施；2)高度发达 协作性和综合性协作计划；3)实施系统的临床研究方法 在所有机构中，包括新的智能IRB Reliance Model审查；以及4)实施了高度 建立在合作伙伴之间前所未有的信任基础上的有效治理体系。洛杉矶猫咪是 根据关键指标评估，研究效率呈指数级增长，包括三倍 外部赠款奖增加，作者承认LA的出版物增加了两倍多 CATS中心的资源和服务，600多名研究人员从我们的服务中受益并使用我们的服务。值得注意的是， 在这段时期，经历了来自COVID和飓风的独特和前所未有的挑战 Ida，洛杉矶CATS已经实现并在许多情况下超过了其宣布的目标和计划的里程碑。 事实上，自2020年3月COVID大流行袭击路易斯安那州以来，洛杉矶猫已经多次成功获得赠款 申请行政补充和NOSI奖励，特别是为了促进COVID检测和 通过RADx-UP计划和最近我们的 与Idea State IScore财团就国家长期COVID倡议--急性后遗症--建立伙伴关系 SARS-CoV-2感染(PASC)/恢复试验。然而，我们充分认识到，我们的工作只是刚刚 随着我们共同解决不平等问题并改善我们公民的生活，我们的努力开始了。同样显而易见的是，慢慢地， 但可以肯定的是，我们正在一次一个项目地影响公共卫生！提出了新服务，并增加了 将增加的资源，我们的中心处于独特的地位，将我们的活动和资源投入到我们的主要 下一个五年周期的主题将是“解决健康差距和改善 我们所服务的公民“。

Project Summary: Overall The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center is the lead institution and will continue to partner with Louisiana State University Health (LSUH)-New Orleans and Tulane University Health Sciences Center in this initiative. LSUH-Shreveport, LSU-A&M (Baton Rouge), Xavier University and Children's Hospital New Orleans, were early Research Partners in cycle 1. Southeast Louisiana Veterans Healthcare System, a newly opened University Medical Center in New Orleans ($1 billion State investment), Ochsner Health and the LSUH-NO School of Dentistry joined during cycle 2. The LA CaTS Center is growing a unified clinical translational science program for Louisiana based on the creation of synergistic programs and unparalleled collaboration from all the major academic and biomedical research institutions in the state. Since inception 9 years ago, the LA CaTS Center has: 1) successfully leveraged resources and expertise of multiple participating institutions to build a vibrant statewide research infrastructure; 2) developed highly synergistic and integrative collaborative programs; 3) implemented a systematic approach to clinical research across all institutions, that includes a new SMART IRB Reliance Model review; and 4) implemented a highly effective governance system based on an unprecedented level of trust between partners. LA CaTS is experiencing exponential growth in research productivity as assessed by key metrics including a three-fold increase in external grant awards, a more than two-fold increase in publications with authors acknowledging LA CaTS Center resources and services and over 600 researchers benefiting from and using our services. Notably, during a period that has been marked by unique and unprecedented challenges from COVID and then Hurricane Ida, LA CaTS has achieved, and in many cases exceeded, its stated objectives and projected milestones. Indeed, since the COVID pandemic hit Louisiana in March of 2020, LA CaTS has led multiple successful grant applications for Administrative Supplements and NOSI awards, notably to facilitate COVID testing and vaccinations in underserved Black communities through the RADx-UP program and most recently our partnership with the IDeA state ISCORE consortium on the national Long-COVID initiative - Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)/RECOVER trial. However, we fully recognize that our work has only just begun, as we collectively address disparities and improve the lives of our citizens. It is also apparent, that slowly, but surely, we are impacting public health one project at a time! With new services proposed and the additional resources that will be added, our Center is uniquely positioned to devote our activities and resources to our major theme for the next 5-year cycle that will “address health disparities and improve the health outcomes of the citizens we serve”.