Administrative Core

摘要 共同组成北方俄亥俄州酒精中心（NOAC）的调查人员是一群世界级的 来自基础科学和临床科学的广泛学科的研究人员，从化学和 从生物化学、代谢和遗传学到临床胃肠病学、肝病学和病理学。我们的目标是 继续在北方俄亥俄州的调查人员之间发展强有力的跨学科合作， 我们对酒精诱导的组织的分子机制和病理生理学的理解的进展 酒精性肝病（ALD）是指酒精性肝病（ALD）引起的肝脏损伤。因为我们的坚强 翻译和临床专业知识，我们也专注于这些基本机制的翻译，以临床 实践NOAC的行政核心将促进这些研究目标的实现 通过以下具体目标和临床实践：1）鼓励NOAC研究者之间的互动， 北方俄亥俄州科学界的核心领导人和管理人员以及研究人员和学员 与NOAC的主题目标相关的利益。行政核心将促进这些互动 通过组织丰富和教育方案，包括每月会议和年度务虚会， 国家海洋和大气管理局，以及邀请世界知名专家访问国家海洋和大气管理局作为访问科学家和提供旅行 参加RSA年度会议或戈登酒精和酒精末研究会议的学员将获得奖励 器官损伤，2）通过提供早期， 共享大型数据集和生物信息学支持。3)提供监督和加强发展 通过组织指导委员会会议和内部会议， 外部咨询委员会。4)管理中心的整体运营预算，并为中心拨款准备预算报告 5）监测研究组成部分和试点项目的进展，并协助任何管理 问题.行政核心实现这些具体目标将加快发现的交付 实现NOAC的长期目标，将基础科学的新发现转化为具体的 乙醇破坏细胞和器官功能的机制成为酒精的有效治疗策略- 引起组织损伤。

ABSTRACT The investigators working together to form the Northern Ohio Alcohol Center (NOAC) are a group of world class investigators from a broad range of disciplines spanning basic and clinical sciences, from chemistry and biochemistry, metabolism and genetics, to clinical gastroenterology, hepatology and pathology. Our goal is to continue to develop strong interdisciplinary collaborations between investigators in Northern Ohio that will lead to advances in our understanding of the molecular mechanisms and pathophysiology of alcohol-induced tissue injury, with a particular, but not exclusive focus, on alcoholic liver disease (ALD). Because of our strong translational and clinical expertise, we also focus on the translation of these basic mechanisms to clinical practice. The Administrative Core of the NOAC will facilitate the accomplishment of these goals for research and clinical practice through the following specific aims: 1) Encourage interactions between NOAC investigators, Core Leaders and managers, as well as investigators and trainees in the Northern Ohio scientific community with interests related to the thematic goals of the NOAC. The Administrative Core will facilitate these interactions via the organization of enrichment and educational programs including monthly meetings and annual retreat of the NOAC, as well as inviting world-renowned experts to visit NOAC as visiting scientists and providing travel awards for trainees to attend the RSA annual meeting or Gordon Research Conference on Alcohol and End Organ Injury, 2) Facilitate systems-wide integrated analysis of ethanol-induced tissue injury by providing early, shared access to large data sets and bioinformatics support. 3) Provide oversight and enhance development of resources for the activities of the NOAC by organizing meetings of the Steering Committee and Internal and External Advisory Boards. 4) Manage the overall operating budget and prepare budget reports for Center grant renewals and 5) Monitor progress of Research Components and Pilot Projects and assist with any management issues. Accomplishment of these specific aims by the Administrative Core will speed the delivery of discoveries towards the long-term goal of the NOAC to translate the novel findings of basic science regarding the specific mechanisms by which ethanol disrupts cellular and organ function into effective treatment strategies for alcohol- induced tissue injury.