Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood Disease

项目摘要 本次更新申请的目标是继续我们的K12培训计划，为早期职业儿科医生， 无论是资质和激情，成为下一代的基础和转化医学科学家。的 我们第一个供资周期的结果非常好，吸取的经验教训被纳入进一步加强 节目该计划的首要主题是阐明分子和细胞发病机制 儿童疾病，从而确定治疗目标。我们的重点是职业发展， 以下是范德比尔特拥有国际公认的发现计划和记录的领域 卓越的研究导师：1）肺部疾病和发展，2）心脏病和发展; 3)肥胖和代谢（包括糖尿病）4）神经系统疾病; 5）癌症生物学，6）遗传学和 基因组医学，和7）传染病，包括新兴病原体。该计划提供了一个综合的 儿科系和医学院的培训计划，为四名儿科K12学者提供最多三个 多年的支持，包括密集的科学指导和个性化的职业发展。学者 将有机会获得一个良好的师资队伍，包括33个精心挑选的高级调查员，所有与 持续的NIH资助以及指导早期职业学者的成功记录。另外，我们有 选择了8名儿科“下一代导师”，K或早期R 01资金将很好地定位于全面 未来的导师。儿科系完全融入范德比尔特医学院 和卫生系统，一个领先的NIH资助的学术医疗中心。所有部门医院研究部门 实验室和核心设施位于一个单一的校园，提供一个综合的研究环境， 学者通过多种培训赠款，有一个强大的管道未来K12学者。项目领导 还将进行全国搜索，以确定一组K12学者，包括代表性不足的少数民族， 在这种合作环境中茁壮成长每个学者将有一个个性化的培训计划 由PI和培训主任与多学科导师团队合作开发，并将 得到广泛的机构和部门资源的支持。每个学者的主要重点将是 是他们的指导研究项目，但他们将有机会参加一系列培训， 支持他们的研究和职业发展目标的机会。为了避免在研究时间分心， 我们将从可选的计划机会中仔细定义所需的活动。所需要素包括每周 参加实验室会议，与他们的主要导师，每月与项目负责人的小组会议，6- 每月举行一次学者监督委员会会议，并对学者和项目进行年度评估。他们还将 与两名外部顾问（Arnold Strauss博士和乔治多佛博士）进行保密的面对面会议。 这些计划为培养下一代儿科医生科学家提供了最佳环境。

Project Summary The goal of this renewal application is to continue our K12 training program for early career pediatricians with both the aptitude and passion to become the next generation of basic and translational physician scientists. The results of our first funding cycle have been excellent, and lessons learned are incorporated to further strengthen the program. The overarching theme for the program is elucidation of the molecular and cellular pathogenesis of childhood diseases, leading to identification of therapeutic targets. Our focus is career development in the following areas where Vanderbilt has internationally recognized programs of discovery combined with a record of excellence in research mentorship: 1) Lung Disease and Development, 2) Heart Disease and Development; 3) Obesity and Metabolism (including diabetes) 4) Neurological Disorders; 5) Cancer Biology, 6) Genetics and Genomic Medicine, and 7) Infectious Diseases, including emerging pathogens. The program offers an integrated pediatric department and medical school training program for four pediatric K12 scholars to receive up to three years of support that includes intense scientific mentorship and personalized career development. The scholars will have access to a cadre of well-established faculty including 33 carefully selected senior investigators, all with sustained NIH funding coupled with a successful track record of mentoring early career scholars. Also, we have selected 8 pediatric ‘next generation mentors’, with K or early R01 funding that will be well positioned for full mentorship in the future. The Department of Pediatrics is fully integrated into the Vanderbilt School of Medicine and health system, a leading NIH funded academic medical center. All departments, hospitals, research laboratories and core facilities reside on a single campus offering an integrated research environment for scholars. Through multiple training grants, there is a strong pipeline of future K12 scholars. Program leadership will also conduct a national search to identify a group of K12 scholars, including underrepresented minorities, that will thrive in this collaborative environment. Each scholar will have an individualized training program developed by the PI and training directors in collaboration with a multidisciplinary mentorship team and will be supported by a broad array of institutional and departmental resources. The primary focus for each scholar will be their mentored research project, but they will have opportunities to participate in an array of training opportunities to support their research and career development goals. To avoid distraction from research time, we will carefully define required activities from optional program opportunities. Required elements include weekly attendance at lab meetings and with their primary mentor, monthly group meetings with program leaders, six- monthly scholar oversight committee meetings, and annual evaluations of scholars and program. They will also have confidential face-to-face meetings with two outside advisors (Drs. Arnold Strauss and George Dover). These plans provide an optimal environment for developing the next generation of pediatric physician scientists.