Predoctoral Training in Developmental Biology

项目摘要 我们寻求更新支持，每年培养12名博士生在发育和干细胞 生物学（DSCB）研究生课程在UCSF。DSCB计划建立在细胞生物学的基础之上， 生物化学和遗传学，以灌输对发育和发育障碍的深刻理解。为 发育生物学领域正在迅速发展，我们为学生提供一个充满活力的，跨学科的 教育，包括最新的概念和实验进展。我们的学生获得 为发育生物学做出开创性贡献的概念和技能，他们的成果就证明了这一点 开创性的发现和成功的科学事业。DSCB是一个学位授予，跨校园的毕业生 该计划由执行委员会管理，并由董事和副董事运行。63名教师 来自十九个基础科学和临床部门的成员参加了该计划。教师是领导者， 他们各自的领域，拥有活跃的研究实验室，并为DSCB学生提供广泛的指导。 每年的务虚会、研讨会、每年的学生- 举办专题讨论会，两个每周期刊俱乐部，教师研究会谈，联合研究会议，并分享学生 监管从1994年至2010年，该培训补助金支持学习发育生物学的学生 通过两个更广泛的研究生课程。2011年，DSCB作为一个独立的研究生课程成立 有自己的招生和课程。从那时起，DSCB在以下两个方面都有了显着的增长： 教师（35至62人）和学生（6至46人，2018年秋季增加到54人）。学生团体已经成为 越来越多样化和最高水平。学生们从蓬勃发展的论文研究实验室和 教师致力于卓越的研究生教育。在上一个资助期间，我们继续 为了进一步加强培训经验，做出改变。这些变化包括：（1）更新 课程包括更强调批判性思维，严格的实验设计，定量和 数据的统计合理解释、可视化和书面解释。(2)更多机会 开发、撰写、展示和辩护拟议的项目，（3）对导师培训的新重视，（4）更多 支持导航论文年，（5）开发程序，以帮助学生确定和执行 理想的职业道路，（6）教师参与研究生课程的所有活动，（7）更强大 行政支助;（8）更全面地开展负责任的研究行为培训。成功 该方案得到了学员在培训期间和培训之后的成果的很好支持，这些成果定期 在社区内外进行测量、总结和透明展示。认识到 成功，UCSF继续扩大其承诺，该计划在财政和行政。 更新这项培训补助金将支持DSCB学生的智力发展，确保每个 毕业生是一位独立的科学家，在未来几十年内帮助领导发育生物学领域。

PROJECT SUMMARY We seek to renew support for training 12 predoctoral students per year in the Developmental and Stem Cell Biology (DSCB) Graduate Program at UCSF. The DSCB program builds off of a foundation of cell biology, biochemistry and genetics to instill deep understanding of development and developmental disorders. As the field of developmental biology is rapidly advancing, we provide our students a dynamic, interdisciplinary education that incorporates the most recent conceptual and experimental advances. Our students acquire the concepts and skills to make groundbreaking contributions to developmental biology, as evidenced by their pioneering discoveries and successful scientific careers. DSCB is a degree-granting, cross-campus graduate program governed by an Executive Committee and run by a Director and an Associate Director. 63 faculty members in 19 basic science and clinical departments participate in the program. The faculty are leaders in their respective fields, have active research laboratories, and provide extensive mentorship to DSCB students. Interactions among laboratories and trainees are facilitated by an annual retreat, seminars, an annual student- run symposium, two weekly journal clubs, faculty research talks, joint research meetings, and shared student supervision. From 1994-2010, this training grant supported students who studied developmental biology through two broader graduate programs. In 2011, DSCB was established as an independent graduate program with its own admissions and its own curriculum. Since then, DSCB has grown dramatically both in terms of faculty (35 to 62) and students (6 to 46, increasing to 54 in Fall 2018). The student body has become increasingly diverse and of the highest caliber. Students chose from thriving thesis research laboratories and faculty dedicated to excellence in graduate education. During the last funding period, we have continued to make changes in order to further strengthen the training experience. These changes include: (1) updating of the curriculum to include greater emphasis on critical thinking, rigorous experimental design, quantitative and statistically sound interpretation, visualization and written interpretation of data. (2) more opportunities to develop, write, present, and defend proposed projects, (3) new emphasis on mentorship training, (4) more support in navigating dissertation years, (5) development of programs to help students determine and execute desired career path, (6) involvement of faculty across all activities of graduate program, (7) more robust administrative support, and (8) more fully developed training in responsible conduct in research. Success of the program is well supported by outcomes of trainees both during and following training, which are regularly measured, summarized, and transparently presented both inside and outside the community. Recognizing the success, UCSF has continued to expand its commitment to the program both financially and administratively. Renewal of this training grant will support the intellectual growth of DSCB students, ensuring that each graduate is an independent scientist who helps lead the field of developmental biology for decades to come.