Training Program in Computational Genomics

项目摘要 宾夕法尼亚大学在过去的20年里培养了计算基因组学家， NHGRI T32计划，培训了52名博士前和13名博士后学员，其中大多数 都投身于研发事业在这里，我们建议继续我们的计算 基因组培训计划，8名博士前和2名博士后学员专注于这一主题 数据科学和机器/统计学习方法应用于基因组学数据。我们的培训 该计划集中在一个严格的课程为基础的课程，由多个课程的支持 毕业生群体。此外，我们的培训还包括13-16小时的负责任行为， 研究（RCR）和科学严谨性和再现性（SRR）培训，个人发展计划， 以及利用电子笔记本和代码库。研究培训是加强了双重 只要有可能，就采用导师制。我们的计划得到了更大的基因组学培训的支持 程序由三个NHGRI T32程序在计算基因组学（这个程序），基因组学 医学和ELSI，以及NHGRI R25多样性行动计划（DAP）。特别是， 该计划招募URM本科生和毕业生，重点是大费城地区 它的许多机构为城市城市居民提供服务。这种纵向区域一体化将使我们能够 培养具有基因组学本科研究经验的URM学生的区域管道。 我们的方案由31名培训员组成，其中14名是女科学家，2名是URM科学家。二十 我们的31位培训师中有一位有一个活跃的计算基因组学研究项目。的专门知识 培训人员涵盖疾病基因组学、基因组技术、多维统计、算法、数据 科学和机器学习。我们的培训环境得到了关键设施的加强，包括大型 生物库，高通量基因组学核心，高性能计算核心，以及独特的沉浸式 数据可视化工具。宾夕法尼亚大学总共举办了60多个NIH培训项目， 管理培训计划的机构行政支持，包括生物医学办公室 博士后项目，多样性和包容性办公室，生物医学研究生联合研究， 还有其他的我们培训计划的成功将有助于培养下一代基因组工作人员 在必要的技能和知识，应用最先进的计算技术，基因组学和 为新的基因组数据开发新技术。

Project Summary University of Pennsylvania has trained computational genomicists for the past 20 years supported by the NHGRI T32 program, training 52 predoctoral and 13 postdoctoral trainees the majority of whom have gone on to careers in research and development. Here we propose to continue our Computational Genomic Training program with eight predoctoral and two postdoctoral trainees focused on the theme of Data Science and Machine/Statistical Learning methods as applied to genomics data. Our training program concentrates on a rigorous course-based curriculum supported by courses in multiple graduate groups. In addition, our training also involves 13-16 hours of Responsible Conduct of Research (RCR) and Scientific Rigor and Reproducibility (SRR) training, Individual Development Plan, and utilization of Electronic Notebooks and code repositories. Research training is enhanced by a dual mentorship model whenever possible. Our program is supported by a greater genomics training program consisting of three NHGRI T32 programs in Computational Genomics (this program), Genomic Medicine, and ELSI, as well as a NHGRI R25 Diversity Action Plan (DAP). In particular, the DAP program recruits URM undergraduate and postbacc trainees focused on the Greater Philadelphia Area whose many institutions serve the urban URM population. This vertical regional integration will allow us to develop a regional pipeline of URM students with undergraduate research experience in genomics. Our program consists of 31 trainers of which 14 are female scientists and 2 are URM scientists. Twenty one of our 31 trainers have an active computational genomics research program. The expertise of the trainers span disease genomics, genomic technologies, multidimensional statistics, algorithms, data sciences, and machine learning. Our training environment is enhanced by key facilities including large biobanks, high-throughput genomics core, high-performance computing core, and a unique immersive data visualization facility. Penn overall hosts more than 60 NIH training programs with strong institutional administrative support for managing the training programs including an Office of Biomedical Postdoctoral Programs, Office of Diversity and Inclusion, combined Biomedical Graduate Studies, among others. Success of our training program will help train the next generation of genomic workforce in the skills and knowledge necessary to apply state-of-art computational techniques to genomics and develop new techniques for novel genomic data.