Renewal: Strategies and Methods for Complex Molecule Synthesis

项目总结/摘要 该计划的目标是开发新的策略和方法， 生物活性次级代谢产物（天然产物）。的很大一部分 我们的努力将致力于确定这些复杂的有效准备工作， 分子。这些化合物及其独特的衍生物将作为新型的小分子化合物， 分子来对抗一系列与癌症相关的适应症， 炎症和疼痛。我们的合成研究将导致C-H，C-C的新应用 和C-N键的功能化方法， 骨架编辑的概念及其在制备拓扑 复杂分子最后，与合作者合作，我们将获得独特的进入 使用天然产物及其衍生物干扰生物功能， 最终为新疗法提供有希望的起点。

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–H, C–C and C–N bond functionalization methodology in organic synthesis as well as advancing the concept of skeletal editing and its application to the preparation of topologically complex molecules. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.