Technology-based Treatments for Substance Use Disorders

总体核心中心项目摘要 数字疗法，提供基于科学的，针对物质使用的行为改变干预 疾病（SUD）和相关问题（包括艾滋病毒风险行为和精神健康障碍）可以明显 改善获得护理的机会、护理质量和治疗结果，同时降低成本， 不同环境中的观众。我们的跨学科小组获得了P30“卓越中心”资助， NIDA 9年前推出了一个新的研究中心（技术和行为健康中心[CTBH]）。 CTBH在数字治疗的开发，实证测试和实施方面处于领先地位 针对SUD和相关问题。在这次更新申请中，我们建议在这项工作的基础上， 活动，以解决最及时和最重要的研究领域的优先事项：（1）加强我们的 与广泛的科学、临床、行业和政府合作伙伴开展协作，以扩大访问范围 在美国及其他地区以科学为基础的数字疗法;（2）扩大活动，将CTBH的 数字健康测量的创新研究，为个性化数字治疗提供信息;（3）加速 研究和指导对物质使用和共同发生的精神和 身体健康状况（COD）;（4）扩大数字健康伦理的研究和资源;（5）扩大 数字健康研究人员的多样性和包容性，通过增加导师和代表性 在数字健康研究中代表性不足的少数民族。P30中心的总体目标是： 跨多个学科的专业知识，并提供基础设施，以提高质量，实现速度， 创新科学研究的影响，将以科学为基础的行为改变干预与 创建、评估和传播针对SUD的数字疗法的科学技术， 共现疾病（COD）。CTBH将通过5个核心实现这一目标：（1）治疗开发和 评估核心将提供资源和培训，以提高研究的质量、效率和影响 并支持加快数字健康评估和治疗科学发展的机制 (2)传播和执行核心将传播研究方法和研究结果， 对在不同环境中成功实施数字治疗的科学理解，（3） 新兴技术和数据分析核心将加强教育和研究的应用 新兴技术和数据分析，以数字治疗，并支持共享资源，以提高 数字治疗的发展速度和潜力，（4）试点核心将支持 新的研究领域，在试点阶段之后，可以通过外部资金进行更大规模的测试，以及 (5)行政核心将提供方案领导，确保成功协调 跨核心的活动和基础设施，以加强我们的跨学科团队之间的协同作用。

OVERALL CORE CENTER PROJECT SUMMARY Digital therapeutics that deliver science-based, behavior change interventions targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and mental health disorders) can markedly improve access to care, quality of care, and treatment outcomes, while reducing costs, for a wide array of audiences in diverse settings. Our interdisciplinary group received a P30 “Center of Excellence” grant from NIDA 9 years ago to launch a new research center (the Center for Technology and Behavioral Health [CTBH]). CTBH has led the field in the development, empirical testing, and implementation of digital therapeutics targeting SUDs and related issues. In this renewal application, we propose to build on this work and grow activities to address the most timely and significant research priorities for the field to: (1) enhance our collaborative work with a wide array of scientific, clinical, industry, and governmental partners to scale access to science-based digital therapeutics across the U.S. and beyond; (2) expand activities to link CTBH’s innovative research in digital health measurement to inform personalized digital therapeutics; (3) accelerate research and mentorship on transdiagnostic digital treatments for substance use and co-occurring mental and physical health conditions (CODs); (4) expand research and resources on digital health ethics and (5) broaden the diversity and inclusiveness of digital health researchers by increasing mentorship and representativeness of underrepresented minorities in digital health research. The Overall Aim of the P30 Center is: To integrate expertise across multiple disciplines and provide an infrastructure to enhance the quality, pace of achievement, and impact of innovative scientific research that combines science-based behavior change interventions with state-of-the-science technologies to create, evaluate, and disseminate digital therapeutics targeting SUDs and co-occurring disorders (CODs). CTBH will achieve this Aim via 5 Cores: (1) The Treatment Development and Evaluation Core will provide resources and training to enhance the quality, efficiency, and impact of research and support mechanisms to accelerate the state-of-the science of digital health assessments and therapeutics (2) The Dissemination and Implementation Core will disseminate research methods and findings and advance a scientific understanding of successful implementation of digital therapeutics in diverse settings, (3) The Emerging Technologies and Data Analytics Core will enhance education and research on the application of emerging technologies and data analytics to digital therapeutics and support shared resources to enhance the pace of development, and potency of, digital therapeutics, (4) The Pilot Core will support the development of new areas of research that could progress to larger-scale testing via external funding after the pilot phase, and (5) The Administrative Core will provide programmatic leadership that ensures successful coordination of activities across Cores and an infrastructure to enhance synergy among our interdisciplinary team.