MARVEL: A Multidisciplinary Assessment of Risks from Vaping during Early Life

摘要-总体 拟议的计划项目，对早期生命中Vaping风险的多学科评估（项目 MARVEL），采用综合方法评估电子烟行为和依赖性的出现; 阐明vaping对青少年健康的影响;并生成经过验证的信息，以减少 青少年vaping。2020年，19.6%的高中生，代表300多万青少年，报告说， 上个月vaping。此外，报告经常使用电子烟的高中生比例有所增加 实质上。在理解当前青年vaping模式方面存在重大差距， 电子烟和依赖，电子烟对健康的影响，以及如何最好地阻止青少年电子烟的激增。 该计划项目的总体目标是：（1）评估含尼古丁电子烟产品的使用情况 以及vaping和依赖症状出现之间的关系，包括个人， 人际关系和环境因素，可能会缓和vaping的影响;（2）确定vaping如何 通过对仍然存在的关键生理和心理系统的影响，破坏健康和福祉 在青春期发展;和（3）评估预防电子烟信息的潜在影响， 基于MARVEL项目中出现的健康危害证据， vaping影响青少年的身体和生活。提出了四个项目，由四个核心支助。 项目1将评估vaping和依赖性出现之间的关系，描述vaping如何 影响青少年福祉的发展，并确定青少年如何看待的影响， 在他们的日常生活中吸烟。项目2将研究电子烟，神经发育， 自主调节和认知/心理技能。项目3将确定vaping如何影响 通过检查症状、功能和气道的早期分子改变来改善呼吸系统健康。项目4将 开发，优化和评估有关vaping的新健康危害的信息，在项目1-3中确定， 现存的文学作品，能引起高中生的共鸣。行政核心将管理业务 对于MARVEL项目，促进项目之间的互动，并协调研究参与。的 生物统计学核心将确保我们的设计和分析最大限度地提高有效性，普遍性和效率。的 青少年研究支持核心将解决进行研究的独特挑战， 增加来自多所学校的青少年人数，促进招聘和留用，确保保护人权， 主题，并保持和利用社区伙伴关系。最后，生物标志物和产品评价 核心将描述最常用的产品，并提供暴露的客观标记， 生物效应MARVEL项目有可能大大提高我们对电子烟如何 影响青少年健康，以及如何最好地进行干预，以减少在这个关键的发展时期的vaping。

ABSTRACT – OVERALL The proposed program project, A Multidisciplinary Assessment of Risks of Vaping in Early Life (Project MARVEL), takes an integrated approach to assessing vaping behavior and the emergence of dependence; elucidating the impact of vaping on adolescent health; and generating empirically-tested messages to reduce adolescent vaping. In 2020, 19.6% of high school students, representing over 3 million adolescents, reported past month vaping. Moreover, the proportion of high school students who report frequent vaping has increased substantially. Significant gaps exist in understanding current patterns of youth vaping, the relationship between vaping and dependence, the impact of vaping on health, and how best to stem the surge in adolescent vaping. The overarching aims of this program project are to: (1) Assess the use of nicotine-containing vaping products and the relationship between vaping and the emergence of symptoms of dependence, including individual, interpersonal, and environmental factors that may moderate the impact of vaping; (2) Determine how vaping disrupts health and well-being through its impact on key physiological and psychological systems that are still developing during adolescence; and (3) Evaluate the potential impact of vaping prevention messages, developed based on emerging evidence of health harms from Project MARVEL and focused on the ways in which vaping affects adolescents’ bodies and lives. Four projects are proposed, supported by four cores. Project 1 will assess the relationship between vaping and the emergence of dependence, describe how vaping impacts the development of adolescent well-being, and determine how adolescents perceive the impact of vaping on their daily lives. Project 2 will examine the association between vaping, neurodevelopment, autonomic regulation, and cognitive/psychological skills. Project 3 will determine how vaping impacts respiratory health by examining symptoms, function, and early molecular alterations in airways. Project 4 will develop, optimize, and evaluate messages about novel health harms of vaping, identified in Projects 1-3 and the extant literature, that resonate with high school students. The Administrative Core will manage operations for Project MARVEL, facilitate interactions between projects, and coordinate study participation. The Biostatistics Core will ensure our designs and analyses maximize validity, generalizability, and efficiency. The Adolescent Research Support Core will address the unique challenges of conducting research with a large number of adolescents from multiple schools, facilitate recruitment and retention, ensure protection of human subjects, and maintain and leverage community partnerships. Finally, the Biomarker and Product Evaluation Core will characterize the most commonly used products and provide objective markers of exposure and biological effect. Project MARVEL has the potential to greatly improve our understanding of how vaping impacts adolescent health and how best to intervene to reduce vaping during this critical developmental period.