Administrative Core

摘要 桑福德研究中心癌症生物学研究中心（CCBR）的行政核心（核心A）是 这不仅对CCBR内的所有研究活动至关重要，而且对桑福德研究所内的研究活动也至关重要 作为一个整体。第三阶段申请的资金将继续为主要研究员提供支助， 项目协调员和项目经理。这些关键人物负责全面管理 的CCBR。我们还建议全力支持首席研究技术员和高级研究专家 组织学和成像核心（核心B）以及流式细胞术核心的经理和技术员 (Core C）。此外，我们还将支持一项试点赠款计划，以确保创新研究的持续资助。 以及CCBR科学核心的使用。指导委员会，由前CoBRE成员组成 项目负责人以及桑福德研究领导人将确保科学核心的成功运作。 一个由癌症生物学领域领导人组成的外部咨询委员会将与外部专家合作， 来自北达科他州州立大学、行政核心和指导委员会的评审员， 试点补助金的授予和解决任何可能出现的问题，在CCBR或其科学核心。的 行政核心将实现以下具体目标：1）支持现有的科学核心， 2）继续试点赠款计划。为了实现这些目标， 行政核心将与指导委员会和外部咨询委员会每年举行两次会议（秋季和春季）。 春季会议将作为对科学核心工作的计划和评估的审查 走向自我可持续性。重要的是，行政核心将优先考虑和监督资金的分配， 以满足机构战略需求并符合NIH的使命。而且 行政核心将继续专注于CCBR现有的癌症研究领域，同时扩大到 包括其他创新和有影响力领域。CCBR将重点关注以下领域：1）肿瘤 神经支配，2）肿瘤免疫应答，3）肿瘤微环境和4）肿瘤发展。最终 行政核心的目标是继续资助该地区的癌症研究， 科学的核心是自给自足。本节中列出的计划将确保CCBR的成功。

Abstract The Administrative Core (Core A) of the Center for Cancer Biology Research (CCBR) at Sanford Research is not only essential for all research activities occurring within the CCBR but also for that within Sanford Research as a whole. The funds requested in Phase III will provide continued support for the Principal Investigator, Program Coordinator and Project Manager. These key individuals are responsible for the overall administration of the CCBR. We also propose to fully support the Lead Research Technician and Senior Research Specialist of the Histology & Imaging Core (Core B) as well as a Manager and Technician in the Flow Cytometry Core (Core C). We will additionally support a Pilot Grant program to ensure continued funding of innovative research in the region and use of the CCBR's Scientific Cores. A Steering Committee composed of previous CoBRE Project Leaders as well as Sanford Research leaders will ensure successful functioning of the Scientific Cores. An External Advisory Committee, composed of leaders in the Cancer Biology field, will work with external reviewers from North Dakota State University, the Administrative Core and the Steering Committee to select Pilot Grant awardees and resolve any issues that may arise within the CCBR or its Scientific Cores. The Administrative Core will accomplish the following Specific Aims: 1) To support the existing Scientific Cores, enabling self-sufficiency and 2) To continue a program of Pilot Grants. In order to achieve these goals, the Administrative Core will meet twice a year (Fall and Spring) with the Steering and External Advisory Committees. The Spring meeting will serve as a review of the program and evaluation of the Scientific Cores as they work towards self-sustainability. Importantly, the Administrative Core will prioritize and oversee the allocation of funds such that they meet institutional strategic needs and are in line with the NIH mission. Moreover, the Administrative Core will continue to focus on the CCBR's existing areas of cancer research while expanding to include additional innovative and impactful areas. The CCBR will have the following focus areas: 1) tumor innervation, 2) tumor immune response, 3) tumor microenvironment and 4) tumor development. The ultimate goals of the Administrative Core are to continue funding cancer research in the region and to bring the CCBR's Scientific Cores to self-sufficiency. The plan laid out in this section will ensure success of the CCBR.