Institutional Training in the Genomic Sciences

摘要 威斯康星大学麦迪逊分校的基因组科学培训计划(GSTP)是 建立一个由领先的基因组科学家组成的包容性社区，其优势横跨 多学科。我们建议的培训机会和环境将使我们的 受训人员创建并严格应用源自以下技术进步的新工具 掌握先进的统计和计算方法，实现多种功能 和大型数据集。生物学和医学研究的基因组学新方法 要求具有多个领域知识和技能的科学家以有效的方式 强化新的见解或发明。因此，新工具的出现允许 创建和解释大规模的实验工作是GSTP关注的重点 从多个领域(生物学、 遗传学、物理科学、工程学、计算机科学和统计学) 个人轮廓，以补充学员的核心学科重点，但建立在 基因组科学中的成就和知识。鉴于令人难以置信的丰富的科学和 在威斯康星大学的工程学广度，GSTP已经能够招聘到优秀的 极大地改进了质谱学、“组学”--整合、计算、基因组 工程和生物设备，同时探索利用这些优势的新应用 网络基因组学、蛋白质组学、空间基因组学、代谢组学、 和基因组生物学。这些成就和贡献孕育和成长了一个 重要的基因组学社区。这个基因组学社区已经成为 跨部门、中心、学校开展开创性协作的中心中心 以及其他培训项目。我们建议在即将到来的项目期内继续这样做 重点，继续强调创新/发明和促进临床应用， 这将推动翻译基因组学的发展，并“将发现转化为健康”。我们要求提供资金 每年10个博士后和4个博士后培训。在下一个资助期，我们将 继续招聘和培训最近完成本科或 研究生学位。

Abstract The Genomic Sciences Training Program (GSTP) at the University of Wisconsin-Madison is building an inclusive community of leading genomic scientists with strengths spanning across multiple disciplines. The training opportunities and environment we propose will enable our trainees to create and rigorously apply new tools derived from technological advances that are informed by cutting-edge statistical and computational approaches that functionalize diverse and large datasets. The new genomic approaches to biological and medical investigation demand scientists who are knowledgeable and skilled across several fields in effective ways that potentiate new insights or inventions. Accordingly, the emergence of new tools allowing for the creation and interpretation of large-scale experimental efforts is what GSTP has focused on by the didactical interweaving of investigative approaches drawn from multiple fields (biology, genetics, physical sciences, engineering, computer science, and statistics) that were individually contoured for complementing a trainee’s core disciplinary focus, yet built upon achievement and knowledge within the genomic sciences. Given the incredibly rich scientific and engineering breadth of the University of Wisconsin, GSTP has been able to recruit outstanding trainees who greatly advanced mass spectrometry, “omic”-integration, computation, genome engineering, and bio-devices, while exploring new applications leveraging these advantages for cutting-edge investigation into network genomics, proteomics, spatial genomics, metabolomics, and genome biology. These achievements and contributions have nucleated and grown a significant genomics community. This genomics community has become a gateway and central hub for groundbreaking collaborations reaching across departments, centers, schools and other training programs. We propose for the upcoming project period that we continue this focus, with continued emphasis on innovation/invention and fostering of clinical applications, which will advance translational genomics and “turn discoveries into health.” We request funding for 10 predoctoral and 4 postdoctoral traineeships per year. In the next funding period, we will continue to recruit and train trainees who have recently completed their undergraduate or graduate degrees.