Translational studies in allergic reactions and inflammation

在2023财年，我们继续推进我们对促进肥大细胞反应、过敏反应和过敏性炎症的获得性和遗传性遗传变化的理解。在本财年我们报道的进展中，最重要的是一篇手稿，证明了类胰蛋白酶基因分型--当与血清类胰蛋白酶蛋白水平结合使用--在识别髓系肿瘤患者时的有效性。我们还报道了类胰蛋白酶基因组成对食物过敏反应严重程度的影响。最后，作为国际合作努力的一部分，我们还发表了一项关于STAT6在人类中的功能获得的里程碑式研究。

In Fiscal Year (FY) 2023, we continued to advance our understanding of acquired and inherited genetic changes that promote mast cell reactivity, anaphylaxis, and allergic inflammation. Foremost among the advances we reported this FY, was a manuscript demonstrating the usefulness of tryptase genotyping - when used in combination with serum levels of the tryptase protein - in identifying patients with myeloid neoplasms. We also reported the impact of tryptase gene composition on the severity of food allergic reactions. And finally, as part of an international collaborative effort, we also published a landmark study on STAT6 gain-of-function in humans.