Core 3: Biostatistics, Data Management, and Bioinformatics

项目摘要 生物统计和生物信息学核心(核心3)的主要目标是提供集中的生物统计， 生物信息学，以及对所有项目和核心的数据库支持。核心3将在设计中提供指导，并 进行临床试验和正在进行的孢子研究所产生的其他试验，以促进 基础科学、临床前和临床研究数据的前瞻性收集、录入、质量控制和集成 临床研究，并提供高通量和高维基因组学的生物信息学数据分析 数据。我们将提供创新和量身定制的统计建模、模拟技术和数据分析 主要项目、发展研究和职业提升项目，以及实现其目标的其他核心 明确的目标。我们将进行数据分析，并准备所有实验的统计报告 项目，确保适当解释所有项目的结果，并协助所有项目调查人员 在科学成果的出版方面。核心3也将是孢子内和孢子间协作的资源， 包括多中心临床试验的研究设计和数据库开发。

Project Summary The major objective of the Biostatistics and Bioinformatics Core (Core 3) is to provide centralized biostatistics, bioinformatics, and database support for all Projects and Cores. Core 3 will provide guidance in the design and conduct of clinical trials and other experiments that arise from the ongoing research of the SPORE, facilitate prospective collection, entry, quality control, and integration of data for the basic science, pre-clinical, and clinical studies, and provide bioinformatics data analysis of high-throughput and high-dimensional genomics data. We will provide innovative and tailored statistical modeling, simulation techniques, and data analyses for the main projects, developmental research and career enhancement projects, and other cores to achieve their specific aims. We will conduct data analyses and prepare statistical reports for all experiments within all projects, ensure that the results of all projects are appropriately interpreted, and assist all project investigators in the publication of scientific results. Core 3 will also be a resource for intra- and inter-SPORE collaborations, including study design and developing databases for multi-center clinical trials.