INTRAVASCULAR MAGNETIC RESONANCE TECHNIQUES

描述(改编自申请者摘要)：早期诊断和 监测动脉粥样硬化的进展和消退有 在对抗世界头号致命心脏的斗争中至关重要 疾病。磁共振成像和波谱方法提供了 关于形态和化学成分的有价值的信息 动脉粥样硬化斑块，但受低信噪比和低 图像分辨率。我们建议开发一种新的血管内磁化 磁共振成像方法，将涉及使用磁共振探头在尖端 导管。这将使动脉粥样硬化具有更完整的特征。 并提供了一种监测介入治疗的新方法 目前还不可能进行的治疗。这个项目的具体目标是 包括开发一种新实时MR荧光透视技术(5 帧/秒)，用于导管探头的三维可视化，以及 用于实现近显微分辨率成像的新型编码技术 (100微米)和高度局域光谱。申请者建议 在幻影、狗和高胆固醇饮食的动物身上验证这些技术 动脉粥样硬化兔模型。血管内磁性的研究进展 共振技术将导致一种创新、实用的系统，它将 常规用于动脉粥样硬化的诊断以及 监测各种介入技术，如激光治疗。

DESCRIPTION (Adapted from Applicant's Abstract): Early diagnosis and monitoring of the progression and regression of atherosclerosis have a crucial importance in the fight against the world's number one fatal heart disease. Magnetic resonance imaging and spectroscopy methods provide valuable information about the morphology and chemical composition of atherosclerotic plaques but suffer from low signal-to-noise ratio and low image resolution. We propose to develop a new intravascular magnetic resonance imaging method that will involve using an MR probe on the tip of a catheter. This will allow more complete characterization of atherosclerotic plaques as well as providing a novel method of monitoring interventional therapy that is not currently possible. The specific aims of this project include the development of a novel real-time MR fluoroscopy technique (5 frames/sec) for 3-D visualization of a catheter probe, and the development of novel encoding techniques to achieve near-microscopic resolution imaging (100 microns) and highly localized spectroscopy. The applicants proposed to validate these techniques on phantoms, dogs and on a high cholesterol-fed atherosclerotic rabbit model. The development of intravascular magnetic resonance techniques will lead to an innovative, practical system that will be used routinely for the diagnosis of atherosclerosis as well as for monitoring various interventional techniques such as laser therapy.