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Chronic graft-versus-host disease

Chronic graft-versus-host disease
慢性移植物抗宿主病
批准号：
10925942
负责人：
Edward Cowen
金额：
$37.88万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10925942
关键词：
Annual ReportsBibliographyBiologyBiopsyClinicalCollaborationsCutaneousErythrocytesFibrosisImmunologicsLeukapheresisManuscriptsPaperPatientsPhenotypePrognostic MarkerPublishingReportingSafetySkinSpecimenTechnologyUnited States National Institutes of HealthWidthchronic graft versus host diseasegraft vs host diseaseinnovationkidney dysfunctionskin disordertranscriptome sequencing

项目摘要

项目成果

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中文摘要
翻译
该项目是一项长期临床合作，是NIH大型内部努力的一部分，旨在推进慢性移植物抗宿主病（GVHD）的研究和治疗。使用临床标本（皮肤活检）以及广泛表型的患者材料，我们的目标是在该领域取得重要进展。这导致自上一份年度报告以来出版了几份手稿。去年的进展包括皮肤GVHD的全面的2部分CME， GVHD患者白细胞摘取的安全性。，红细胞分布宽度作为cGVHD的预后指标，以及GVHD患者肾功能障碍的预测指标。一份关于CGVHD纤维化的RNA序列报告正在JID Innovations上进行修订。
英文摘要
This project is a long-term clinical collaboration as part of a large intramural NIH effort to advance the study and treatments of chronic graft-versus-host disease (GVHD). Using clinical specimens (skin biopsies) as well as extensively phenotyped patient material, we aim to make important advances in the field. This has led to several published manuscripts since the last Annual Report. Advances in the last year include a comprehensive 2 part CME of cutaneous GVHD, safety of leukapheresis in GVHD pts., red cell distribution width as a prognostic marker of cGVHD, and predictors of kidney dysfunction in GVHD. A report on RNA seq of CGVHD fibrosis is under revision to JID Innovations.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease.
慢性移植物抗宿主病患者肾功能障碍的预测因子和意义。
DOI： 10.1038/s41409-023-02032-1
发表时间： 2023
期刊： Bone marrow transplantation
影响因子： 4.8
作者： [Beshensky,David, Pirsl,Filip, Holtzman,NoaG, Steinberg,SethM, Mays,JacquelineW, Cowen,EdwardW, Comis,LeoraE, Joe,GalenO, Magone,MTeresa, Schulz,Eduard, Waldman,MerylA, Pavletic,StevenZ]
通讯作者： Pavletic,StevenZ
Determinants and Clinical Significance of Musculoskeletal Symptoms in Patients With Chronic Graft-Versus-Host Disease.
DOI： 10.1097/hs9.0000000000000730
发表时间： 2022-06
期刊： HEMASPHERE
影响因子： 6.6
作者： [Kerep, Ana Zelic, Pirsl, Filip, Steinberg, Seth, Mitchell, Sandra, Curtis, Lauren, Holtzman, Noa, Goklemez, Sencer, Bilic, Ervina, Cowen, Edward, Pichard, Dominique, Joe, Galen, Comis, Leora, Im, Annie, Berger, Ann, Parsons-Wandell, Laura, Pulanic, Drazen, Baird, Kristin, Gress, Ronald, Pavletic, Steven]
通讯作者： Pavletic, Steven
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海外基金