Administrative Core

行政核心项目摘要 我们的自身免疫卓越中心提案的总体目标是调查 自身抗体的产生机制，有助于SLE的发病机制。 三个单独的项目将审查与初步归纳有关的基本问题， 自身抗体，产生它们的B细胞，交叉反应性和自身抗体的调节 在SLE患者中产生B细胞（主要和试点项目）， TNF抑制剂诱导狼疮相关自身免疫性炎性关节炎 （合作项目）。行政核心将是我们ACE运作的核心， 提供预算和财务监督，通过管理与临床 将为拟定的转化研究招募患者的研究者， 生物统计监督，并提供后勤支持，以促进内部的科学互动 范斯坦ACE，与合作者和其他ACE成员。核心将是共同的， 由安妮·戴维森博士和贝蒂·戴蒙德博士执导，他们在合作方面有着丰富的经验。 研究，并将在管理与合作者的互动中发挥补充作用。在 此外，行政核心将得到已建立的临床基础设施的支持， 包括大型患者库、完善的患者队列、专家临床合作者、IRB 批准的数据和血液采集方案，经验丰富的生物统计学合作者， 适当的科学技术。所有调查人员之间的密切关系 和合作者以及我们的长期行政人员应确保顺利运作 并成功实施所有项目。

Administrative Core Project Summary The overall goal of our Autoimmunity Center of Excellence proposal is to investigate mechanisms for the production of autoantibodies that contribute to the pathogenesis of SLE. Three individual projects will examine basic questions related to initial induction of autoantibodies, the B cells that produce them, cross-reactivity and regulation of autoantibody producing B cells in patients with SLE (Principal and Pilot Projects) and in patients with inflammatory arthritis that develop lupus-related autoimmunity induced by TNF inhibitors (Collaborative Project). The Administrative Core will be central to the functioning of our ACE by providing budgetary and financial oversight, by managing interactions with the clinical investigators who will be recruiting patients for the proposed translational studies, by providing biostatistical oversight and by providing logistical support to facilitate scientific interactions within the Feinstein ACE, with collaborators and with other ACE members. The Core will be co- directed by Drs Anne Davidson and Betty Diamond who have vast experience with collaborative studies and will have complementary roles in managing interactions with collaborators. In addition, the Administrative Core will be supported by an established clinical infrastructure that includes a large patient pool, well-established patient cohorts, expert clinical collaborators, IRB approved protocols for data and blood collection, an experienced biostatistics collaborator and appropriate scientific technology. The close existing relationships between all the investigators and collaborators and with our long time administrative staff should ensure smooth functioning of the Core and successful implementation of all projects.