QUANTITATIVE PERFORMANCE ASSESSMENT OF THE AIDS DEMENTIA COMPLEX

这个新项目旨在扩展神经心理学的工作， 在项目启动初期完成评估。 其 目的是扩展目前的量化绩效方法 ADC的评估，重点是更敏感的措施，可能证明 在多学科研究中有价值， ADC的病理生理机制。 从一个标准化的 程序，该项目将建立一个连续的效用 绩效任务（CPT），使用持续反应时间测量 注意ADC特性。 CPT作为一种敏感、早期 在抗逆转录病毒疗法研究中衡量治疗效果， 针对潜在的神经病理生理机制的治疗， 还将研究ADC。 作为CPT测量的相关性，其 相应的事件相关电位（ERP）也将被研究， 关于ADC CPT和事件相关的潜在措施将 在FDG/PET扫描期间与项目4合作进行研究。 的 这些研究的目的不是为了取代以前建立的 ADC的神经心理学评估方法，但要发展更多 这种综合征中敏感的损伤指标， 在研究治疗效果和潜力方面的重要作用 病理生理机制 在本方案中，这些 研究将与局部脑的研究相结合， 代谢，定量MRI和EEG功率谱，并将发挥作用， 在使用直接替代标记物进行相关研究中的重要作用 以及HIV-1感染对CNS的间接影响。

This new project seeks to extend the work on neuropsychological assessment accomplished in the Program's initial period of funding. Its objective is to extend the current method of quantitative performance evaluation of ADC, focussing on more sensitive measures that might prove valuable in multidisciplinary studies directed at the underlying pathophysiological mechanism of ADC. Starting with a well-standardized procedure, this project will establish the utility of a Continuous Performance Task (CPT), using a reaction time measure of sustained attention to characterize ADC. The utility of CPT as a sensitive, early measure of treatment effects in studies of anti-retroviral therapy and of therapies directed at potential neuropathophysiological mechanisms of ADC will also be studied. As a correlate of the CPT measure, its corresponding event related potential (ERP) will also be studied with respect to ADC. Both the CPT and event related potential measures will be studied during FDG/PET scanning in collaboration with Project 4. The objective of these studies is not to replace the previously established methods of the neuropsychological assessment of ADC, but to develop more sensitive measures of impairment in this syndrome that can play a significant role in studying treatment effects and potential pathophysiological mechanisms. In the context of this Program, these studies will be integrated with the studies of regional cerebral metabolism, quantitative MRI, and EEG power spectra, and will play an important role in correlative studies using surrogate markers of direct and indirect effects of HIV-1 infection of the CNS.