GENETICS OF AFFECTIVE DISORDERS

这项研究的主要目的是检测基因效应 躁郁症和相关的情感障碍。这个目标一定会实现的 了1.收集扩展的高密度谱系， 疾病; 2.使用综合的临床表型表征 临床评级和操作诊断标准; 3.进行 与DNA标记的连锁研究;和4.重新评估联系 导致先前确定的具有X连锁证据的谱系 通过扩展和更新临床和遗传学 信息.在联系分析得出结果之前， 目标将包括：疾病的识别和表征 基因;临床和临床上连锁疾病形式的表征 生物措施;基因-环境相互作用的阐明; 扩大谱系名册，以复制联系结果， 评估病因异质性;以及一项旨在延长 并更新已经确定的谱系。三个人口将是 研究：一般北美样本;犹太裔美国人（哈西德派） “隔离”;和一个以色列样本。这将有助于评估 人群之间的遗传和文化差异。的可用性 一系列独特的谱系，加上最近的诊断进展， 程序，分子遗传技术，和连锁分析，持有 有望解开某些形式的遗传机制， 严重的情感性疾病反过来，这可能对 对病因学、疾病分类学、病理生理学的影响， 预防和治疗这些疾病。 候选人的持续专业发展将持续下去， 由1培养。在执行《公约》过程中将获得的经验 建议研究; 2。广泛的合作和协商， 该领域的其他专家; 3.课程、研讨会和讲习班 相关学科; 4.利用独特的部门 致力于精神病遗传学的资源和环境。

The broad objective of the proposed research is to detect gene effects in bipolar and related affective disorders. This goal will be attained by 1. collecting extended high-density pedigrees segregating these disorders; 2. characterizing the clinical phenotype using comprehensive clinical ratings and operational diagnostic criteria; 3. conducting linkage studies with DNA markers; and 4. re-evaluating the linkage results in previously identified pedigrees with evidence of X-linked transmission by extending and updating the clinical and genetic information. Pending the results of the linkage analyses, long-range goals will include: identification and characterization of the disease gene(s); characterization of linked disease forms on clinical and biological measures; elucidation of gene-environment interaction; expansion of the pedigree roster to replicate linkage results and to assess etiologic heterogeneity; and a follow-up study aimed at extending and updating the pedigrees already identified. Three populations will be studied: a general North-American sample; a Jewish-American (Hasidic) 'isolate'; and an Israeli sample. This should allow assessment of genetic and cultural differences among populations. The availability of a unique series of pedigrees, coupled with recent advances in diagnostic procedures, molecular genetic techniques, and linkage analysis, holds promise for unraveling the genetic mechanisms that underlie some forms of major affective illness. This, in turn, may have important implications for the etiology, nosology, pathophysiology and, possibly, prevention and treatment and treatment of these disorders. The candidate's continued professional growth will be sustained and fostered by 1. the experience to be gained during the conduct of the proposed research; 2. extensive collaborations and consultations with other experts in the field; 3. courses, seminars and workshops in the relevant disciplines; and 4. utilization of unique departmental resources and environment dedicated to psychiatric genetics.