VITAMIN D DEFICIENCY AND PROSTATE CARCINOMA

前列腺癌是癌症死亡的第二大原因。 在美国的男性中。尽管重要的是 对于这种癌症，人们对其病因知之甚少。建议数 一项研究调查了维生素D缺乏症可能 是前列腺癌的危险因素。这一假设是有根据的 关于前列腺地理分布的观察 癌症与紫外线的可获得性密切相关， 维生素D水平的主要决定因素。越高 在黑人和白人中观察到的前列腺癌发病率 美国，以及美国黑人和非洲黑人之间的关系，也是 可在维生素D缺乏的基础上解释。这个 假设与最近的实验数据是一致的 提示维生素D可抑制细胞因子的表达 在人类前列腺癌细胞中扩增的癌基因。这个 假说将在50名患者的病例对照研究中得到验证 前列腺癌和良性前列腺癌患者50例 肥大作为对照。病例和对照将进行比较 关于他们的血清维生素D浓度 代谢物和D结合蛋白的等位基因分布。 皮肤色素沉着和日晒习惯的差异将 也被测量和比较。

Prostate cancer is the second largest cause of cancer mortality among males in the United States (U.S.). Despite the importance of this cancer, little is known about its etiology. The proposed study investigates the hypothesis that Vitamin D deficiency may be a risk factor for prostate carcinoma. This hypothesis is based on the observation that the geographic distribution of prostate cancer parallels closely the availability of ultraviolet radiation, the principle determinant of Vitamin D levels. The higher prostate cancer rates observed among Blacks versus Whites in the U.S., and between U.S. Blacks versus African Blacks, are also interpretable on the basis of Vitamin D deficiency. The hypothesis is consistent with recent experimental data which indicate that Vitamin D inhibits the expression of cellular oncogenes that are amplified in human prostate cancer cells. The hypothesis will be tested in a case-control study of 50 patients with prostate carcinoma and 50 patients with benign prostatic hypertrophy as controls. Cases and controls will be compared with respect to their serum concentrations of Vitamin D metabolites and the allelic distribution of D-Binding Protein. Differences in skin pigmentation and solar exposure habits will also be measured and compared.