Immune-neuron crosstalk regulates intestinal homeostasis

鉴于肠道作为一个主要的内分泌器官，从环境信号到神经内分泌反应的有效转换对身体生理至关重要。由于肠道组织中含有大量的微生物群和免疫细胞，因此肠道组织中充满了多种免疫调节因子。免疫系统和神经内分泌系统之间的协调对环境感知和宿主防御至关重要。我们的工作旨在破译免疫-神经调节肠粘膜稳态的细胞和分子机制。此外，已知肠道神经内分泌反应不仅影响局部生理，而且影响全身生理。我们的数据表明，肠道免疫介导的神经内分泌反应协调了全身生理和炎症。

Given that the gut functions as a major endocrine organ, the efficient translation from environmental cues to neuroendocrine responses is essential for body physiology. By harboring large quantities of microbiota and immune cells, the intestinal tissue is filled with a variety of immune regulators. Coordination between the immune system and the neuroendocrine system is essential for environmental sensation and host defense. Our work seeks to decipher the cellular and molecular mechanisms of immune-neural regulation for intestinal mucosal homeostasis. Further, the intestinal neuroendocrine responses are known to impact not only local but also systemic physiology. Our data establish that intestinal immune-mediated neuroendocrine responses orchestrate systemic physiology and inflammation.