Animal care: supporting research on pathogenesis and treatment of autoimmunity

NIAMS IRP动物项目监督了使用小鼠、大鼠、鱼和兔模型的25项动物研究提案（ASP）。 在NIAMS，有大量的研究围绕关节炎，重组/染色质重塑使用AID转基因小鼠，家族性地中海热（FMF）和TNF受体相关的周期性综合征。也有大量的研究涉及肌肉和相关疾病（实验：N-RAP蛋白，糖原累积病II型，SIRT 1基因，肌原纤维组装，肌炎，包括药物诱导，和声音产生肌肉在海军军官学校鱼）和亚细胞细胞器和骨骼肌细胞骨架的研究。NIAMS的研究还包括研究逆转录病毒转导的体外实验，骨髓移植和使用胎儿和成人皮肤组织的表皮分化研究。 该研究所进行的研究涉及过敏性鼻炎和其他传递受体诱导的细胞反应。 该研究所的许多研究涉及细胞凋亡和自身免疫。NIAMS还关注软骨研究，重点是组织工程软骨、软骨形成、GDF-F、COMP和骨关节炎。

The NIAMS IRP Animal Program has oversight for 25 Animal Study Proposals (ASPs) using mouse, rat, fish, and rabbit models. At NIAMS, there is a great deal of research around arthritis, recombination/chromatin remodeling using AID transgenic mice, familial Mediterranean fever (FMF) and Tnf receptor associated periodic syndrome. There is also a great deal of research involving muscle and related diseases (experimentation with: N-RAP protein, glycogen storage disease Type II, SIRT1 gene, myofibril assembly, myositis including drug induced, and the voice generating muscle in Midshipman fish) and the study of sub-cellular organelles and cytoskeleton in skeletal muscle. Studies at NIAMS also include in vitro experiments studying retroviral transduction, bone marrow transplantation, and epidermal differentiation studies using fetal and adult skin tissues. Research involving allergic rhinitis and other transmit receptor-induced cellular responses is conducted at the institute. Many of the institutes studies involve apoptosis and autoimmunity. Also of interest within NIAMS are cartilage studies focused on tissue-engineered cartilage, chondrogenesis, GDF-F, COMP and osteoarthritis.