CORE B-Data Management, Harmonization, and Information Transfer Core

核心B项目摘要 核心B(数据管理、协调和信息传输核心)负责 促进分析阿尔茨海默氏病序列项目(ADSP)数据和其他相关数据 项目通过处理和协调所有相关的基因和功能基因组学(FG)数据。 核心B将管理所有表型、基因、注释和分析结果，并分发 所有ADSP研究人员和NIA遗传学阿尔茨海默病数据存储站点的数据/文件 (NIAGADS)，NIA指定的AD遗传学研究合格访问库。特定的 目标是：(1)接收和管理所有相关的基因、表型和功能基因组 数据；(2)从测序数据中调用SNV、INDELs和结构变体(SVS)；(3)开发 具有GCAD WGS数据的GCAD单倍型参考板，用于GWAS归责；(4)促进 通过制定数据处理和组学的最佳做法来协调FG/组学数据 协调ADSP FG计划与其他相关组学数据的协调；(5)支持 GCAD信息技术需求和信息传播活动。

Core B Project Summary Core B (Data Management, Harmonization, and Information Transfer Core) is responsible for facilitating analysis of Alzheimer’s Disease Sequence Project (ADSP) data and other relevant projects by processing and harmonizing all relevant genetic and functional genomics (FG) data. Core B will manage all phenotype, genotype, annotation, and analysis results, and distribute data/files to all ADSP investigators and to NIA Genetics of Alzheimer’s Data Storage Site (NIAGADS), the NIA-designated qualified access repository for AD genetics research. Specific Aims are: (1) Receive and manage all relevant genotypic, phenotypic, and functional genomic data; (2) Calling SNVs, indels and structural variants (SVs) from sequencing data; (3) Develop a GCAD haplotype reference panel with GCAD WGS data for GWAS imputation; (4) Facilitate harmonization of FG/omics data by developing best practices for data processing and coordinate harmonization of ADSP FG Program and other relevant omics data; (5) Support GCAD information technology needs and information dissemination activities.