2009 Kern Aspen Lipid Conference

描述（由申请人提供）： 本申请旨在为2009年克恩白杨脂质会议“核受体和辅调节剂在胰岛素抵抗、能量和脂质代谢、炎症、心血管疾病和衰老调节中的作用”寻求资金，该会议将于2008年8月22日至25日在科罗拉多的白杨举行。这将侧重于核激素受体，转录因子和辅助调节因子如何调节脂质和能量代谢，这些代谢与胰岛素抵抗，炎症，氧化应激和免疫的发病机制密切相关，在肥胖，代谢综合征，糖尿病和衰老中的心血管，肾脏和肝脏疾病中发挥关键作用。 第一部分将着重于各种核激素受体和辅助调节因子如何调节能量代谢和线粒体生物合成。演讲者将包括：特里马拉托斯弗里尔（波士顿），卡尔图梅尔（犹他州），娜塔莎克拉利（圣地亚哥），布鲁斯斯皮格曼（波士顿）：弗雷德克恩讲师。第一次会议之后将举行全体海报会议和开幕招待会。 第二节将确定新型核激素受体和G蛋白偶联受体在营养代谢和衰老过程中的作用。演讲者将包括：Sudha Biddinger（波士顿），Makoto Kuro-o（达拉斯），Steven Kliewer（达拉斯）和Johan Auwerx（法国）。第二场会议之后将举行海报会议和午餐。 第三节将进一步确定各种核激素受体和辅助调节因子如何调节碳水化合物和脂质代谢。发言人将包括：肖恩伯吉斯（达拉斯），杰拉尔德舒尔曼（纽黑文），卡罗琳康明斯（多伦多）和大卫L。威廉姆斯纪念讲座奖：从申请者中选出。第三场会议之后将举行海报会议和午餐。 第四节将集中在核激素受体和转录因子如何调节炎症和动脉粥样硬化，包括巨噬细胞的功能。演讲者将包括：丹尼尔梅茨格（法国），阿贾伊Chawla（帕洛阿尔托），丹利特曼（纽约）和克里斯玻璃（圣地亚哥）：捷豹路虎讲师。 (End摘要）

DESCRIPTION (provided by applicant): This application seeks funding for the 2009 Kern Aspen Lipid Conference "Role of Nuclear Receptors and Coregulators in Modulation of Insulin Resistance, Energy and Lipid Metabolism, Inflammation, Cardiovascular Disease and Aging" which will be held in Aspen, Colorado on August 22-25, 2008. This will focus on how Nuclear Hormone Receptors, Transcriptional Factors and Coregulators modulate lipid and energy metabolism which are closely linked to the pathogenesis of insulin resistance, inflammation, oxidative stress, and immunity, which play a critical role in cardiovascular, renal, and liver disease in obesity, metabolic syndrome, diabetes, and aging. Session 1 will focus on how the various nuclear hormone receptors and coregulators modulate energy metabolism and mitochondrial biogenesis. Speakers will include: Terry Maratos-Flier (Boston), Carl Thummel (Utah), Natasha Kralli (San Diego), Bruce Spiegelman (Boston): Fred Kern Lecturer. Session 1 will be followed by a Plenary Poster Session and opening reception. Session 2 will determine the role of novel nuclear hormone receptors and G protein coupled receptors in regulation of nutrient metabolism and the aging process. Speakers will include: Sudha Biddinger (Boston), Makoto Kuro-o (Dallas), Steven Kliewer (Dallas), and Johan Auwerx (France). Session 2 will be followed by Poster Session and lunch. Session 3 will further determine how the various nuclear hormone receptors and coregulators modulate carbohydrate and lipid metabolism. Speakers will include: Shawn Burgess (Dallas), Gerald Shulman (New Haven), Carolyn Cummins (Toronto), and David L. Williams Memorial Lectureship Award: to be chosen amongst applicants. Session 3 will be followed by Poster Session and lunch. Session 4 will focus on how nuclear hormone receptors and transcriptional factors modulate inflammation and atherosclerosis, including macrophage function. Speakers will include: Daniel Metzger (France), Ajay Chawla (Palo Alto), Dan Littman (New York), and Chris Glass (San Diego): JLR Lecturer. (End of Abstract)