Ecological and Evolutionary Functional Genomics

描述（由申请人提供）：该提案要求为即将于2009年7月12日至17日在新罕布什尔州蒂尔顿的蒂尔顿学校举行的生态和进化功能基因组学（EEFG）戈登研究会议（GRC）提供部分资金。会议的长期目标是促进跨生态学，进化和基因组学领域研究人员之间的跨学科互动。该提案的具体目标是召集25-30名发言者组成的多元化小组，以及总共135名与会者参加这一为期五天的互动会议。我们已经得到了蜜蜂基因组项目领导人Gene罗宾逊教授（伊利诺伊大学）的承诺，作为主旨发言人。此外，我们计划有会议侧重于以下主题领域：传染病的演变，人口基因组学，进化发育生物学，生态基因组学和压力反应，社区基因组学/宏基因组学，比较基因组学，等等。这一提议的重要性在于，它将构成我们本次会议总体筹资战略的一个关键组成部分，其中涉及向国家科学基金会、私营公司和其他来源提出申请。该应用程序与人类健康相关，因为它将包括关于人类人口基因组学和人口统计学历史的演讲者和会议，这对于了解人类遗传变异的结构至关重要，并且通过扩展，遗传背景中先天性和传染性疾病的出现并在整个物种中传播。 公共卫生相关性：这项申请的健康相关性在于，将资助的会议将包括关于人类人口基因组学和人口统计学历史的演讲者和会议，这对于了解人类遗传变异的结构至关重要，并且推而广之，先天性和传染性疾病在整个物种中出现和传播的遗传背景。会议还将包括一些关于酵母和果蝇等模式物种进化基因组学的会谈和会议。对这些物种的研究在历史上对于进一步研究人类进化遗传学和疾病非常重要，并为人类的类似研究指明了方向。

DESCRIPTION (provided by applicant): This proposal requests partial funding for the upcoming Gordon Research Conference (GRC) in Ecological and Evolutionary Functional Genomics (EEFG), to be held at the Tilton School in Tilton, New Hampshire, July 12-17, 2009. The long-term goal of the conference is to catalyze interdisciplinary interactions between researchers spanning the areas of ecology, evolution and genomics. The specific aims of this proposal are to convene a diverse group of 25-30 speakers, and a total of 135 conference attendees for this five-day interactive meeting. We have already secured the commitment of Professor Gene Robinson (University of Illinois), the leader of the honeybee genome project, as a keynote, plenary speaker. In addition we plan to have sessions focusing on the following topic areas: Evolution of infectious disease, Population genomics, Evolutionary developmental biology, Ecological genomics and stress response, Community Genomics/Metagenomics, Comparative Genomics, among several others. The significance of this proposal is that it will comprise a critical component of our overall funding strategy for this meeting, which involves applications to the National Science Foundation, private companies and other sources. This application has relevance to human health because it will include speakers and session on human population genomics and demographic history, which are critical to understand the structure of genetic variation in humans, and, by extension, the genetic context in which congenital and infectious diseases arise and spread throughout the species. Public Health Relevance: The health relatedness of this application is that the meeting to be funded will include speakers and sessions on human population genomics and demographic history, which are critical to understand the structure of genetic variation in humans, and, by extension, the genetic context in which congenital and infectious diseases arise and spread throughout the species. The meeting will also include a number of talks and sessions on the evolutionary genomics of model species, such as yeast and Drosophila. Studies on such species have historically been very important for furthering the study of human evolutionary genetics and disease, and for pointing the way for similar studies on humans.