New Frontiers in Skeletal Research: Bone, Fat and Brain Connections

描述(由申请人提供)：在过去的十年里，有大量的研究描绘了中枢神经系统在调节新陈代谢、生殖和骨骼转换中的作用。在小鼠身上的开创性发现，但在人类中经常得到证实，定义了通过下丘脑核发出的神经网络将脂肪组织的新陈代谢与骨骼重塑联系起来的相互作用。库欣综合征和神经性厌食症等疾病，以及1型或2型糖尿病、肥胖症和更广泛的代谢综合征等流行疾病，都表明了控制体重和骨量之间的密切关系。从艾滋病毒到精神分裂症，治疗各种疾病的常用治疗剂的不良代谢影响，加强了了解体重和骨量是如何通过神经网络调节的重要性。最近，从骨骼到胰岛和脂肪细胞的离散信号的描绘，调节了胰岛素的产生和敏感性，提供了令人信服的证据，证明骨骼和能量代谢之间存在密切而关键的关系，这种关系的分子细节才刚刚开始出现。内分泌学的这一新兴方面横跨包括新陈代谢、骨生理学和神经学在内的广泛学科，它需要充分探索细胞和分子生物学、遗传学、流行病学、放射学、血液学和神经生理学的工具。因此，应当召开一次会议，在不同学科的主要专家举行的正式会谈和以问答形式进行的非正式讨论以及海报介绍的范围内审议这些进展。由于这一科学领域发展迅速，将强调吸引年轻研究人员参加多学科会议并为他们提供进一步调查机会的重要性。拟议的会议也将是将新知识转化为新的治疗概念的重要一步。此外，本次会议还将确定未来研究的关键问题。美国骨骼和矿物研究学会是研究和推进与骨骼相关的疾病的基础和临床研究的主要学会。上述考虑充分表明，现在是协会提议召开这次会议的最佳时机。我们的长期目标是通过开发一个论坛来促进科学的发展，以建立跨学科的必要合作。它还应该为NIH提供关于未来几年值得支持的计划的新想法，并导致活跃的思想交流和对未来研究和治疗进展的重要途径的定义。

DESCRIPTION (provided by applicant): The last decade has seen a plethora of investigations delineating the role of the central nervous system in regulating metabolism, reproduction and skeletal turnover. Seminal discoveries in mice but often-confirmed in humans have defined the interactions that link metabolism of adipose tissue with skeletal remodeling through neural networks emanating from nuclei in the hypothalamus. Diseases such as Cushing's syndrome and anorexia nervosa, as well as prevalent disorders such as type 1 or 2 diabetes, obesity and more generally the metabolic syndrome, have illustrated the intimate relationship between the control of body weight and of bone mass. Adverse metabolic effects of commonly used therapeutic agents for treating a wide spectrum of diseases from HIV to schizophrenia reinforce the importance of understanding how body weight and bone mass are regulated through neural networks. Most recently, the delineation of a discrete signal from bone to islet and fat cells, modulating both insulin production and sensitivity, provides compelling evidence of an intimate and critical relationship, whose molecular details are only beginning to emerge, between bone and energy metabolisms. This emerging aspect of endocrinology spans a wide spectrum of disciplines including metabolism, bone physiology, and neurology, and it requires tools of cellular and molecular biology, genetics, epidemiology, radiology, hematology, and neurophysiology to be fully explored. As such, it is appropriate to convene a meeting in which these advances can be considered within the context of both formal talks by leading experts from various disciplines and informal discussions in the format of questions and answers as well as poster presentations. Since this scientific field has evolved quickly and dramatically, the importance of drawing young investigators to a multi-disciplinary meeting and providing them with opportunities for further investigations will be emphasized. The proposed meeting will also serve as an important step towards translating new knowledge into new therapeutic concepts. In addition, this meeting will identify key questions for future research. The American Society for Bone and Mineral Research is the premier society for the study and advancement of basic and clinical research in disorders relating to the skeleton. The considerations described above make it abundantly clear that now is a perfect time for the Society to propose this meeting. Our long-term goal is to advance the science by developing a forum for establishing the necessary collaborations across disciplines. It should also provide NIH with novel ideas about programs worthy of support in future years and lead to a vibrant exchange of ideas and a definition of vital pathways for future advances in research and treatment.