Restless Legs Syndrome Scientific Meeting

描述（由申请人提供）：1997年2月22日，第一次不宁腿综合征（RLS）科学会议在华盛顿特区的美国国家科学院召开。十年前，RLS还不是一个家喻户晓的名字。正因为如此，当时成立五年的RLS基金会决定组织一次会议，以激发其他领域的顶级研究人员对这种相对闻所未闻的疾病的兴趣。RLS基金会是一个非营利性的501(c)3组织，致力于改善患有这种毁灭性疾病的男性、女性和儿童的生活。该组织的目标是提高人们对不宁腿综合症的认识，改进治疗方法，并通过研究找到治愈方法。本提案的目的是请求美国国立卫生研究院支持召开关于RLS的第二次科学会议。在过去的十年里，人们对睡眠倒睡症的研究取得了令人难以置信的进展。由RLS基金会部分资助的研究人员最近宣布，他们发现了第一个导致RLS风险的基因变异。我们现在也知道，睡眠脚动症与大脑实质性黑质中的铁缺乏密切相关，这在十年前是我们无法理解的。此外，医疗保健提供者现在有很好的流行病学信息：a)确定准确诊断RLS必须问的确切问题；b)确定美国人群中RLS的发病率。第二次会议的目标是：(1)将RLS基金会的受助人聚集在一起，总结过去10年所做的工作；(2)评估现有的假说，并考虑提出新的假说；(3)吸引新的研究人员进入RLS领域；(4)为RLS基金会的研究项目制定研究重点和明确的重点领域。公共卫生相关性：RLS科学会议反映了2010年健康人：残疾和继发性疾病的目标。会议的目标是为未来的RLS研究制定路线图，这一目标包含在HP 2010的目标中，即促进美国残疾人的健康，预防继发性疾病，消除残疾人和非残疾人之间的差距。

DESCRIPTION (provided by applicant): It was on February 22, 1997 that the first Restless legs syndrome (RLS) Scientific Meeting was held at the National Academy of Sciences in Washington D.C. A decade ago, RLS was anything but a household name. Because of this, the then five-year-old RLS Foundation decided to organize a meeting to spark interest in this relatively unheard of condition among top level researchers in other fields. The RLS Foundation, a nonprofit 501(c)3 organization, is dedicated to improving the lives of the men, women, and children who live with this often devastating disease. The organization's goals are to increase awareness of restless legs syndrome, to improve treatments, and, through research, find a cure. The purpose of this proposal is to request the National Institute of Health's support to convene a second scientific meeting on RLS. The last ten years have seen incredible progress in the study of RLS. Researchers, funded in part of the RLS Foundation, recently announced the discovery of the first gene variant that contributes substantially to risk for RLS. We also now understand that RLS correlates heavily with iron deficiencies in the brain's substantial nigra, something that we did not understand ten years ago. In addition, healthcare providers now have excellent epidemiology information that: a) identifies the exact questions one must ask to get an accurate diagnosis of RLS; and b) pinpoints the incidence of RLS in the American population. The goals of this second meeting would be to: (1) bring RLS Foundation grantee recipients together to summarize what has been done in the past 10 years; (2) evaluate the existing hypotheses and consider the development of new hypotheses as to the cause of RLS; (3) attract new researchers into the field of RLS; and (4) develop research priorities and articulate areas of focus for the RLS Foundation's research program. PUBLIC HEALTH RELEVANCE: The RLS Science Meeting reflects the goals of Healthy People 2010: Disability and Secondary Conditions. The goal of the meeting to create a roadmap for future RLS research is contained within the HP 2010 goal to promote the health of people with disabilities, prevent secondary conditions, and eliminate disparities between people with and without disabilities in the United States.