Catechol-functionalized Coatings for Cardiovascular Medical Devices

描述(申请人提供)：该项目旨在开发新型邻苯二酚官能化聚合物，用于提高润滑性的医疗器械涂层。儿茶酚已被证明是贻贝分泌的附着在水下表面的黏附蛋白的关键成分。邻苯二酚具有许多不同的非共价键相互作用，这有助于增加邻苯二酚官能化分子在有机和无机底物上的粘附性。这种能力将被用来创造与以前难以涂布的医疗器械材料(如硅胶、PEBAX-72和特氟龙)粘合的涂层，从而为增强这些材料的设备性能开辟道路。儿茶酚将通过合成儿茶酚单体并与乙烯基吡咯烷酮共聚来加入，乙烯基吡咯烷酮是一种常用的水凝胶涂层，用于增加涂层的光滑性。虽然儿茶酚以前被附着在其他聚合物上，但它们主要局限于聚乙二醇。该方案的创新之处在于开发了邻苯二酚功能化聚合物，用于改善医疗器械的润滑性涂层。与公共健康相关：这项提案将开发心血管医疗设备的涂层，以增加滑润性和与血液的兼容性。它针对的是设备制造中使用的特定材料，这些材料很难用一种受到贻贝启发的新方法来覆盖。这些以贻贝为灵感的涂层应该可以更容易地插入医疗设备，减少组织损伤和疼痛。改进的医疗设备将改善患者的舒适度和健康。

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX-72 and Teflon, opening the way to enhanced device properties for these materials. Catechols will be incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols have been previously attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. PUBLIC HEALTH RELEVANCE: This proposal will develop coatings for cardiovascular medical devices to increase slipperiness and compatibility with the blood. It targets specific materials used in the device fabrication which are difficult to coat with a novel approach inspired by mussels. These mussel-inspired coatings should allow easier insertion of medical devices with less tissue injury and pain. Improved medical devices will improve patient comfort and health.