Optical Imaging of Tactile Information in S1 Cortex

摘要 这项提议的目标是研究大脑是如何编码触觉运动信息的 大脑。将检查初级躯体感觉皮质(SI)不同区域的反应 (区域3a、3b、1和2)。理解他们的功能角色的核心是找出区别于 从一个地区到另一个地区。通过使用简单刺激和复杂刺激，我们的目标是区分不同的区域 其反应与刺激的物理性质和其区域密切相关 响应是不变的，更接近地反映了运动感知。我们将使用光学成像技术， 电压敏感染料成像、BOLD功能磁共振成像、单单元记录和解剖示踪方法 回答这些问题。这些实验将阐明触觉背后的神经回路。 行为和注意力，理解，将有临床意义的功能恢复 中风与触觉假肢的发展。 2.

ABSTRACT The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics. 2