ULTRASOUND SYSTEM FOR CARDIOVASCULAR PHENOTYPE STUDIES IN HUMANS

描述(由申请人提供)：这是共享仪器拨款(SIG)提案的第一次重新提交，该提案要求使用最先进的GE Vivid 7超声系统，该系统将用于由美国国立卫生研究院和华盛顿大学其他组织赞助的临床研究中对人类进行精致的心血管表型鉴定。所要求的系统将安装在位于华盛顿大学临床研究中心的心血管成像和临床研究核心实验室(CIRCL)并进行操作。这个专用超声系统将取代2000年5月通过SIG机制购买的现有超声系统，到通过目前的提议更换时，将超过9年。目前的超声系统一直是CIRCL的主力，自最初获得以来，心脏和血管超声研究的数量一直在稳步增加。有两个主要问题需要更换：1)该系统多年来一直出现故障，因此难以为目前由国家卫生研究院赞助的用户群体提供服务；2)该用户群体所要求的新技术进步证明有理由购买更现代化的系统。所请求的系统将服务于一个用户群体，该用户群体主要由16名由NIH资助的吴研究员组成，他们代表了不同的学科、部门和部门。用户组的每个成员都成功地使用了本系统，并在过去9年中证明了对该系统的重大需求。所要求的共享仪器将继续对华盛顿大学用户组和临床研究社区目前和未来由NIH支持的研究活动的成功产生重大影响。所要求的系统将由一名技术主任维护和监督，并由CIRCL主任和PI对所要求的仪器进行行政和科学监督。这一最先进的心血管超声成像系统将继续促进用户组研究计划的成功，并促进旨在为临床医学转化性研究表征心脏和心室结构和功能的多学科努力。所要求的超声系统是针对主要研究领域的临床研究的关键，包括：1)高血压心脏病的表型-基因相关性；2)老年、T1糖尿病和绝经后妇女的心脏代谢、结构和收缩/舒张期功能；3)肥胖和体重减轻的心脏/血管功能；4)代谢综合征的血管功能和新药的消退；5)艾滋病毒/艾滋病的心脏/血管功能；6)代谢综合征的血管结构-功能和表型-基因相关性；7)主动脉狭窄的心脏和瓣膜功能；8)超声组织定征；9)镰刀细胞病的心脏功能；10)预防术后深静脉血栓形成的新策略。购买新的超声系统将为用户群体实现他们的NIH资助项目的科学目标提供直接的好处。 公共卫生相关性：心血管疾病是美国发病率和死亡率的主要原因。作为NIH赞助的学术内科科学家，我们的使命是开发诊断和治疗心血管疾病的新方法。所要求的最先进的超声成像设备将继续在NIH赞助的临床研究中评估患有心脏和血管疾病的受试者方面发挥关键作用。

DESCRIPTION (provided by applicant): This is the first resubmission of a Shared Instrumentation Grant (SIG) proposal requesting a state-of-the art GE Vivid 7 Ultrasound System, which will be used for exquisite cardiovascular phenotyping of humans for clinical research studies sponsored by the NIH and other organizations at Washington University. The requested system will be housed and operated in the Cardiovascular Imaging and Clinical Research Core Laboratory (CIRCL) located in the Center for Clinical Studies at Washington University. This dedicated ultrasound system will replace an existing ultrasound system which was purchased through the SIG mechanism in May 2000, and will be 9+ years by the time it is replaced through the current proposal. The current ultrasound system has been the workhorse of CIRCL, where the number of cardiac and vascular ultrasound studies has increased steadily since its original acquisition. Two major issues justify replacement: 1) the system has been malfunctioning for a number of years, thus creating difficulties in serving the current NIH-sponsored user group and 2) new technological advances requested by the user group justify the acquisition of a more modern system. The requested system will serve a user group composed primarily of 16 NIH-funded investigators at WU, representing a diverse range of disciplines, divisions, and departments. Each member of the user group has successfully used the present system, and a significant need for this system has been demonstrated during the past 9 years. The requested shared instrument will continue to have a major impact on the success of current and future NIH-supported research activities of the User Group and the clinical research community at Washington University. The requested system will be maintained and supervised by a Technical Director with administrative and scientific oversight by the CIRCL Director and PI for the requested instrument. This state-of-the-art cardiovascular ultrasound imaging system will continue to promote the success of the user group research programs and facilitate multidisciplinary efforts aimed at the characterization of cardiac and ventricular structure and function for translational studies in clinical medicine. The requested ultrasound system is critical for clinical research studies targeting major research areas, including: 1) Phenotype-genotype correlations in hypertensive heart disease; 2) Cardiac metabolism, structure and systolic/diastolic function in aging, T1DM, and in postmenopausal women; 3) Cardiac/vascular function in obesity and weight loss; 4) Vascular function in metabolic syndrome and regression with novel pharmacologic agents; 5) Cardiac/vascular function in HIV-AIDS; 6) Vascular structure-function and phenotype-genotype correlations in metabolic syndrome; 7)Cardiac and valve function in aortic stenosis and regression with novel pharmacologic agents; 8) Ultrasonic tissue characterization; 9) Cardiac function in Sickle Cell disease; 10) Novel strategies for prevention of postoperative deep venous thrombosis. Acquisition of the new ultrasound system will provide immediate benefit to the user group in accomplishing the scientific goals of their NIH funded projects. PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the major cause of morbidity and mortality in the United States. Our mission as NIH- sponsored academic physician-scientists is to develop new methods for diagnosis and treatment of cardiovascular disease. The requested state-of-the-art ultrasound imaging equipment will continue to play a critical role in the evaluation of subjects with diseases of the heart and blood vessels for NIH-sponsored clinical research studies.