Cancer Center Support Grant

描述(申请人提供)：赫伯特·欧文综合癌症中心(HICCC)于1972年被指定为NCI癌症中心，并于1979年获得综合地位。HICCC是哥伦比亚大学医学中心的一个组成部分，与纽约长老会医院(NYPH)有联系。在2003-07年间，CUMC和NYPH已承诺提供超过3.127亿美元，用于i)基础、临床和人口科学方面的新研究计划；ii)实验室研究和临床活动的新设施和扩建设施；iii)招聘和计划重组；iv)对中心行政办公室的支持；以及v)用于抵消NCI CCSG减少的支持的过渡性资金。 2005年，医学博士里卡多·达拉-法维拉被任命为新主任，他被赋予：i)管理新设施的权力，包括欧文癌症研究中心(ICRC)，这是一座新的10层建筑，致力于癌症研究，在赫伯特·欧文展馆(HIP)拥有最先进的实验室(10万平方英尺)和增加的临床空间(30000平方英尺)；ii)基础广泛的招聘计划，该计划已经吸引了8名新的教员加入HICCC；以及iii)重组和扩大共享资源。主任通过任命一名负责临床研究的副主任和负责基础研究、临床研究、人口科学、生物医学信息学、共享资源和行政管理的副主任，彻底重塑了HICCC的高级领导层。HICCC的计划结构进行了重组，以加强癌症重点和跨学科合作，目前有来自22个部门和6所学校的216名成员，分配到两个基础研究计划(癌症信号网络和癌症遗传学与表观遗传学)，三个疾病特定计划(乳腺癌、前列腺癌和淋巴发育与恶性肿瘤)，以及两个人口科学计划(癌症流行病学和预防、控制与差异)。HICCC总共管理和支持12个共享资源，其中4个是最近创建的。

DESCRIPTION (provided by applicant): The Herbert Irving Comprehensive Cancer Center (HICCC) was designated an NCI Cancer Center in 1972 and gained comprehensive status in 1979. The HICCC is a component of Columbia University Medical Center and associated with New York-Presbyterian Hospital (NYPH). During the period 2003-07, CUMC and NYPH have committed over $312.7 million for i) new research initiatives in basic, clinical and population science; ii) new and expanded facilities for laboratory research and clinical activities; iii) recruitment and program restructuring; iv) support of the Center's administrative office; and v) bridge funding to offset reduced NCI CCSG support. A new Director, Riccardo Dalla-Favera, MD, was appointed in 2005 and given: i) authority over new facilities, including the Irving Cancer Research Center (ICRC), a new 10-story building dedicated to cancer research, with state-of-the-art laboratories (100,000 square feet) and incremental clinical (30,000 square feet) space in the Herbert Irving Pavilion (HIP); ii) a broad-based recruitment plan, which has already attracted 8 new faculty members to the HICCC; and iii) restructuring and expansion of the shared resources. The Director has fully reshaped the senior leadership of the HICCC with appointments of a Deputy Director for Clinical Research and Associate Directors for Basic Research, Clinical Research, Population Science, Biomedical Informatics, Shared Resources and Administration. The programmatic structure of the HICCC has been reorganized to increase cancer focus and interdisciplinary collaboration, and now includes 216 members from 22 Departments and 6 Schools, assigned to two Basic Research programs (Cancer Signaling Networks and Cancer Genetics & Epigenetics), three Disease-Specific programs (Breast Cancer, Prostate Cancer, and Lymphoid Development & Malignancy), and two Population Science programs (Cancer Epidemiology and Prevention, Control & Disparities). The HICCC administers and supports a total of 12 Shared Resources, of which four have been recently created.